皮膚T細胞淋巴瘤患者的人類T淋巴細胞白血病病毒Ⅰ型感染.pdf

1、復旦大學碩士學位論文皮膚T細胞淋巴瘤患者的人類T淋巴細胞白血病病毒Ⅰ型感染姓名：高紅陽申請學位級別：碩士專業(yè)：生物物理學指導教師：單易非2002.5.15堡!：蘭堡堡苧堡壁!塑望壁里墮皇耋塑△鲞!鲞里塑望皂坐塹墮量三型墮!!一InfectionofHumanTLymphotropicVirusTypeIinPatientswithCutaneousTcellLymphomaAbstractCutaneousTcelllymphoma(C

2、TCL)designatesagroupofneoplasmsofTcelllymphoproliferativediseasesthatclinicallyoriginateintheskinorshowobviousmanifastationofskinlesionsItoccupies60％ofcutaneousmalignantlymphomas(CML)andshowsconsiderablevariationinclinic

3、alpresentation，histopathology，immunophenotypeandsoonTheetiologyofCTCLremainsunknownandmayberelatewithagentssuchasvirusinfection，heredity，immunityandenviromentThecourseofCTCLisslowSomestudiessuggestthatCTCLisassociatedwit

4、htheinfectionofhumanTlymphotropicvirustypeI(HTLV—I)HTLVIisakindofhumanretroviruswhichcausesadultT—cellleukemia／lymphoma(ATL／L)ThiskindofvirusisendemicinJapan，theCaribbeanregionandthewesternAfricaSincethegeographicenvirom

5、entinShanghaiandtheareasofJiang—ZhearesimilartoSouthJapanwhereHTLVIisendemic，itisinterestingwhetherthereisHTLV—IinfectionintheseareasornotInthisstudyprovirusDNAofHTLV—IandantibodiestoHTLV1weretestedamong46casesofCTCLpati

6、ents’peripherybloodwhoarelivedaroundShanghaiandJiangZheareaandnevertravelledabroadbyPCR，ELISA，PAandWesternBlot5caseswerefoundtohavepro—virusDNAofHTLVIinPBMCandamongthem3casesshowedpositivewithHTLVIantibodiesinserumThisst