傳染性單核細(xì)胞增多癥外周血B淋巴細(xì)胞CD21的表達(dá).pdf

1、Yfi42924分類號：—R725572—R39212一密級：公玨UDc：一塞塹!!學(xué)號：Q152魚東南大學(xué)碩士學(xué)位論文傳染性單核細(xì)胞增多癥外周血B淋巴細(xì)胞CD21的表達(dá)研究生姓名：張融導(dǎo)師姓名：夔型熬授：申請學(xué)位級刷亟土學(xué)科專業(yè)名稱』L整坐論文提交日期2Q墮生壁2且蝗旦論文答辯日期墊Q生Q2且!旦學(xué)位授予單位盔直塞堂學(xué)位授予口期2Q豎生縣目答辯委員會主席宣道堡評闊人宜道堡2005年09月08日入●^ExpressionofCD21on

2、PeripheralBloodBLymphocytesofPatientswithInfectiousMononucleosisABSTRACTGraduate：ZHANGRongSupervisor：JIANGLiSchoolofClinicalMedicine，SoutheastUniversityInfectiousMononucleosis(IM)iSonekindofviralinfectiousdiseasesinchild

3、hood，andcausedbyEpstein—Barrvirus(EBV)EBVinfects，especiallyBlymphocytes，throughgp320／220bindingtotheCD21molecule，thespecificreceptorofEBVonthecellsurfaceTherefore，theexpressionofCD21relatestothedevelopmentofillnessandits

4、manifestationsobjective：ToinvestigatetheexpressionofCD21onperipheralbloodBlymphocytesofpatientswithIMMethods：38childrenwithIMwereinIMgroup，14neonateswithnoninfectiousdiseasewereincontrolgroupI，14childrenwithnon—infectiou

5、sdiseasewereincontrolgrouplI，theexpressionofCD21onBlymphocytesinIMgroupandtowcontrolgroupswereanalyzedwithflowcytometryTheresultswereanalysedbyCellQuestsoftwareResults：TheratioofBlymphocytesofperipheralblood(2015％1inIMgr

6、oupweresignificantlyhigherthanthatintheneonatalcontrolgroup(941％，p001)andthecontrolgrouplI(1626％，pOO1)；thenumberofBlymphocytesexpressingCD21、andtheMFIofCD21onBlymphocyteweresignificantlyhigherinIMgroupthanthatinthetowcon

7、trolgroups(正005，p001)Conclusions：TheamountsofBlymphocytesexpressingCD21weremuchhigherthanthetwocontrolgroups，thisindicatesthatthedifferentiationandproliferationofBlymphocyteswereincreased，andapoptosisofBlymphocyteswerede

8、creasedafterEBVinfectedTheinfectionofEpsteinBarrvirus(EBV)caninduceBlymphocytestoexpressCD21athigherlevel，makingBlymphocytesmoresensitivetoEBV，andhavingtheabilityoffurthertransformationandproliferationKeywords：Infectious