天然α-生育酚煙酸酯的合成和提純.pdf

1、Y9Q主713洳≥j、碩士學(xué)位論文⑧作者姓名虹避亟指導(dǎo)教師揚(yáng)痊塞到熬援所在學(xué)院撾魁復(fù)絲堂工捏堂醫(yī)天然小生育酚煙酸酯的合成和提純ABSTRACT強(qiáng)es”鋤e畦c齟d沁鑫c撕onpfocess《d噸tocopkrol癌e嘲瀨te嘲sst讖ed，n地syntlleticprocesswasa“onepot，processconsistedofptoluenesuIfonylchloride，芏娃co紐吐c黯id’andd噸一協(xié)co磚efol鑫

2、S鞠_wma把f采，p如d弦e雒cal城yst鋤ld協(xié)lueneassol、嘲1tThesidereactionwasalsostudiedAmethodwaspToposedtodetem洳etlle玉謹(jǐn)一電oco露e∞l嫩eo斑撼峙and山氈協(xié)cophefoltoluene巾一鼢l王bnate羽端mainworkw雒tooptimizethes燦eticpmcessofdn_tocopherolIlicotinatebyUIlifo

3、mDesi印，whichwasfollowedby刪ng謝tha墩liandw啦墨dryingand彝l婦t主ng。確髓，thecrudeproductwaspurifiedbysilkagelcolumnchromatographyUnifbnnDes啦isamethodtoop‰izethereactionc0誠tionsThc瑚m撒scov甜eswerethatt镩。瑚lct王onco嫡《onscou|dbeconsidefedi

4、noneU芏liformDesigntableTheoptimumreactionc鋤dmonswereasfollows：thetemperatureofthe磊撤reac痂nw瑟50℃and盤e重iI艇ewas83min，n圓c娟啦acid№(d噸t?！薨dero玲聃郴287(mol／m01)，n(nicotillicacid)／n0tol獬nesu渤nylchlo耐c)M邯105(撒ol，m01)，n◇酒dh)／n國to|l∞nes

5、ulfoHyle軸碰de)輔as316(mo抽01)，齜幻斌voluIrleofpyridille／d心tocopher01was25(m垤)，thevolumeof‰t01uene／玉靜tocoph湘1w勰35(刪g)，齜捃mpera觚eofthe粼ondreaction啪s98℃and船timew硒138minThercactionyiddofd—atocopherol顫cotinatewasmorethan95％nlctotaly

6、i。ldwasmoreman90％瓢l(fā)epllrityofcrud囂小a—tocophe∞lmcotil嫩tewasmore也an80％Theopt晌llIncondidollsofsilicagelcolunmchromato謦aphywereasf01lo淞：40gsili鞠。g采《g昏一20m％毽，矗l砩婦a20mmad)285婦Amcd瑚黻，w避lVmexalle)：V(ethylacetate)=5：1asnlemobilep

7、hase，thcnowrate2m婦洫，∞omte戳peram糙，啦el∞dofsamples垂攝eeonce翦扭撼oni娃璁emob娃ep婦seO。6∥蕊nep戚夠ofthefinalpmductwasmorctlan95％111ebyproductd_旺tocoph∽ltol∞ne—Ps越稻n蹴，no黻e玨ted玉G一￡oco毋erol，a畦otb暇溉兩矗escouⅪ3王lberem0Vedfbmthecn】deproductKey