血清PSA聯(lián)合Gleason評分與臨床分期預測前列腺癌核素骨顯像的研究.pdf

1、浙江大學碩士學位論文血清PSA聯(lián)合Gleason評分與臨床分期預測前列腺癌核素骨顯像的研究姓名：沈華鋒申請學位級別：碩士專業(yè)：外科學（泌尿外科）指導教師：謝立平20070320SerumPSALevelCombinedwithGleasonScoreandClinicalStagetoPredictRadionuclideBoneScanFindingsinpatientswithprostatecancerDepartmentofSu

2、rgery，MedicalSchoolofZhejiangUniversityPostgraduateSupervisorShenHuafengProfXieLipingAbstractobjective：Toinvestigatetherelationshipbetweenradionuclidebone5Callands@lamprostatespecificantigen(PSA)，Gleasonscore，andclinical

3、stageinprostatecancerMethods：Asurveyhasbeenmadeofinpatientswithprostatecar／octdiagnosedbypathologyfromJanuary1992toJune2005inourhospitalGleasonscoreandclinicalstageweredeterminedonthebasisofpathologicalexaminationandclin

4、icmaterialinprostatecancerpatientsPosRivepredictivevalue(PP叨andnegativepredictivevalue(NP修werecomparedamongdifferentgroupsbasedonPSAandGleasonscorecutoffvaluesin117patientsLogisticregressionanalyseswereusedtoquantifythes

5、trengthofassociationbetweenpositiveSCanSandtheavailableclinicalvariablesResults：TheNPVandPPVofthelowriskgroup(PSA0～10ng／mL，GleasonSeore100ng／mL，Gleasonscore7)are100％，71％and42％，93％，respectivelyInunivariateandmultivariatea

6、nalysis，serumPSAlevel，GleasonSCOreandclinicalstageareallindependentlypredictiveofapositiveboneSeal]ThestrongestpredictorofapositivescanwasserumPSAlevels，especiallythepresenceofserumPSAlevelsof1001500ng／mL，thenextstronges

7、tpredictorwasclinicalstageT3T4Conclusions：RadionuclideboneScansareanunnecessarypartofstagingofprostateoancerifPSA蘭_10ng／mL，especiallywithstageT1，T2andGleasonscore100ng／mLespeciallywithstageT3T4andGleasonscore7【Keywords|P