大學(xué)生抑郁癥的認(rèn)知加工腦機(jī)制及干預(yù)研究.pdf

1、大連理工大學(xué)博士學(xué)位論文大學(xué)生抑郁癥的認(rèn)知加工腦機(jī)制及干預(yù)研究姓名：馬瑩華申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：神經(jīng)信息學(xué)指導(dǎo)教師：唐一源20090601大學(xué)生抑郁癥的認(rèn)知加工腦機(jī)制及干預(yù)研究ResearchontheBrainMechanismandtheInterventionofCognitiveProcessinginDepressionamongCollegeStudentsAbstractDepressionhasbecomeamajor

2、diseasethreateningcollegestudents’psychologicalhealthTomitigateandimprovedepressionamongcollegestudents觴wellasteduceandcontroltheemergenceofdepressionamongcollegestudentsarenotonlyanimportantmedicalsubje甌butalsoaseriouss

3、ocialissueHoweverSOfartheneuropathicpathologicalmechanismofdepressionremainsnotcompletelyclear，especiallyinthetransformationofthecognitivefunctionofthecoresymptomsChapter4ofthisarticle，ofwhichChapter2toChapter4isourmainw

4、ork，focusingonthefollowingthreeissues：(1)nlechangingrulesofnegativeactivationintheemotionalandcognitiveprocessingofdepressedpatientsamongcollegestudentsTakingtheidentificationofaffectivepicturesfromtheInternationalAffect

5、ivePictureSystem(PLC)aSthestimulustasks，functionalmagneticresonanceimaging(伽凹isappliedtocomparethedifferencesofnegativeactivationbetweenthegroupofdepressedstudentsandthecontrolgroupofhealthystudentsinthestateoftasksDatai

6、sanalyzedusingstatisticalparametricmapping(SPM)Comparedtohealthysubjectsgroup，deactivationofdepressivepatientsgroupWasmoresignificantonthewholebrainespeciallyinthecingulategyrus，butnotintheposteriorcingulategyrusTheseres

7、ultssuggestedthatthereallocationofbrainresourcesinthedepressivepatientsgroupduringemotionalcognitivetasksWasaffectedbythecognitivedisfunction，resultinginabnormaldeactivation(2)Thefunctionalconflictmanagingandcognitivepro

8、cessingofbraininthedepressiondiseaseamongcollegestudentsIncombinationwiththeclassicneuropsychologicalmode(Go／Nogo)，thesinglephotonemissioncomputedtomography(SPECT)isadoptedtocollectdataandstatisticalparametricmapping(SPM

9、)isappliedtodothedataprocessingAnobviouschangeisdiscoveredinthecorrespondentpartsofthebrainbloodflowinthegroupofdepressedpatientsandthecontrolgroupofnormalstudentsSpecificallywhenoperatingGo／Nogotasks，thebrainbloodflowin

10、theareasofanteriorcingulatedcortex，themedialprefrontal，lateralinferiorfrontalgymsandcorpuscaUosumrisedramatically，whichimpliesthatdeficiencymayexistinthefunctionsofthesepartsofthebrainanddepressedpatientsamongcollegestud