新型氯蟲酰胺類似殺蟲劑的設計、合成與生物活性研究.pdf

1、南開大學碩士學位論文新型氯蟲酰胺類似殺蟲劑的設計、合成與生物活性研究姓名：劉智力申請學位級別：碩士專業(yè)：化學；有機化學指導教師：李正名201105Abstract一—————_———————————————_———_—————_——_—————_——__———’，————一AbstractOneofthelatestbreakthroughsinpesticideresearchistheR&Dofaseriesofcompoundst

2、argetingattheRyanodineReceptor(RyR)Beingoneclassofsuchcompounds，anthranilicdiamideswasdiscoveredbyDuPontin2000，whichwithitsnewtargetingmachanisms，inducestheactivitionofRyanodinereceptorteleaseendogeIlouScaldumstoreinallu

3、ncontrolledmannerRynaxyp)，r1MWasthefirstcommercializedcompoundfromsuchclass，whichbearsexceptionalactivityonabroadrengeofLepidopteraandhasnocrossresistancetoexistinginsecticides，withitsextraordinaryselectivitytotargetmach

4、enismsecuresitssafetytohumansandotheranimalsBasedonthestructureofRynaxyp—andthemoleculardesignapproachsudlasbioactivesubstructurecoordination41unreportednoVelcompounds，includingthreeseriesofanthranilicdiamidesanaloguesan

5、dtwoseriesofnewimermediates，weredesignedandsynthesizedThestructuresofallcompoundssynthesizedweredeterminedby1HNMR，IRMSandelementalanalysisorHRMSBvmeansoftheestabilshedinsecticidalactivityscreeningsystem，theinsecticidalac

6、tivitiesofthesenewcompoundsweresystematicallytestedTheresultsofthebiologicalassayshowedthatsomeofthemexhibitedgoodinsecticidalactivitiesagainstOrientalArmyworm(MythinmaseparataWalker)andCulexpipiellspallensAmongwhichbyin