碳-碳、碳-氮鍵的構(gòu)建研究.pdf

1、蘭州大學(xué)博士學(xué)位論文碳碳、碳氮鍵的構(gòu)建研究姓名：史雷申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：涂永強(qiáng)20050501黲硇塒蟲掌博士學(xué)位論文史番pT對(duì)YongqiangTuLeiShiAbstractStateKeyLabOfApplOrgChem＆DeptChemLanzhouUniversityMay2005ThisthesisfinishesSomestudiestowards“theEfficientConstruetionofC

2、—CorCXbond”includingmainlythefollowingfourparts1ArapidanddirectaminationofarylhalideshasbeendevelopedingoodtollighyieldundermicrowaveirradiationwithouttransitionmetalcatalystThismethodisespeciallyapplicabletoelectronrich

3、arylhalideswithvariousaminesInsomecases，theexcellentregioselectivitycouldbeobserved，whichfacilitatedthepreparationofmetasubstitutedanilinesfromorthoorparasubstitutedphenylhalidesInadditionamechanismviatheinterestingbenzy

4、neintermediatehasbeenproposed2nwasfirstlyfoundthattheRiekeNigenerated／ns／tuwasabletopromotethepinacolcouplingofvariouscarbonylsefficientlyBasedonthisinformation，anothercatalyticallyeffective，acheaperandmoreconvenientNiCl

5、2(Cat)／Mg／TMSCIsystemwasdesignedanddevelopedfurthersuccessfullyTheinterestingsingle—electrontransfer(SET)mechanismsforthecouplingreactionswereproposedAdditionally，thedl／mesodiastereoseleetivityandsomeadditiveeffectswerea

6、lsoexplainedintermsoftheproposedmechanisms3Anefficientthree—componentcouplingofaldehyde，alkyne，andaminetogeneratepropargylamineshasbeeneffectedundermicrowaveirradiationinwaterusingonlyCuIcatalystwithoutthenoblemetalcocat

7、alystThismethodhasprovedtobeapplicabletoawiderangeofsubstratesInaddition，thepreliminaryexperimentusing(∞一prolinemethylesterasachiralsourcedemonstratedthatitcouldbedevelopedtobeadirectandhighlydiastereoselectivemethodforc