固載的手性催化劑在不對稱Aldol反應中的應用.pdf

1、彳81634委糾犬乎碩士學位論文(2005屆)固載的手性催化劑在不對稱Aldol反應中的應用TheApplicationofimmobilizedchiralcatalystsintheAsymmetricAldolReactions研究生姓名指導教師姓名專業(yè)名稱研究方向馬濟美沈宗旋(教授)有機化學有機合成論文提交日期————墊!!主!旦一一同找的下竹俄化劑存不對稱Aldol反應q1的應用英文摘要ABSTRACT1Synthesisof

2、ImmobilizedChiralCatalystsandApplicationintheAsymmetricAldolReactionsMerrifieldresinsupported(4R)hydroxy一(233一proline，PMBHAresinsupported(433一hydroxy一(233proline，silicasupportedethylcellulose一(2固一proline—ZnCl2and∥cyclode

3、xtrinimmobilized(433phenoxy(233prolineweresynthesizedThecatalyticabilitiesoffourcatalystsontheasymmetricAldolreactionsbetweenacetoneandvariousaromaticaldehydeswerestudiedTheeevalueofthereactionbetweenacetoneandonitrobenz

4、aldehydecatalyzedbyBcyclodextrinimmobilized(4回一phenoxy(2研protinewas834％Thecatalystcouldberecycledbysimplefiltrationandreusedforfourtimes，whiletheyieldsdecreasedappreciablyandthevalueofeeremainedsteadiness2Design，Synthesi

5、sandApplicationofSmallOrganicMolecularCatalystsinAsymmetricBaylisHillmanReactionsFournewchiralorganiccatalysts(21a，21b，23and29)weresynthesizedfromnaturalLphenylalanineandLproline，respectivelyTheinfluenceofthestructureofc

6、atalystsontheasymmetricBaylis—HillmanreactionwasstudiedelementarilyTheproductofmethylvinylketoneandOnitrobenzatdehydecatalyzedby29wasobtainedin897％yieldwith181％eeKeywords：immobilized，chiralcatalyst，asymmetric，Aldolreacti