版權說明:本文檔由用戶提供并上傳,收益歸屬內(nèi)容提供方,若內(nèi)容存在侵權,請進行舉報或認領
文檔簡介
1、Background: Carcinoma of the urinary bladder occurs in highfrequency in china where it is the lOth most common cancer, accountingfor 17,365 deaths in 2005, and mortality has steadily increased between1991 and 2005. Gro
2、wth of solid tumors and the formation of metastases aredependent on both the degree of tumor vascularization and the rate ofangiogenesis. Specific binding of inducers to cellular ligands such asVEGF on endothelial cells
3、triggers the sequence of events leading to theformation of new vessels. The potency to induce angiogenesis is aproperty that has excited the current interest in VEGF. Thus, the potentialof VEGF as a new prognostic factor
4、 and target for anti cancer therapy inhuman bladder cancer at the VEGF protein level was studied. Vascular endothelial growth factor (VEGF) regulatesneovascularization in malignant cells. VEGF as a mitogen is thoug
5、ht toalter cancer cell formation and tumor. Objectives: To study vascular endothelial growth factor (VEGF) inurinary bladder carcinoma and its relationship with pathological stageand histological grade progression; and
6、to evaluate theirhistopathological relevance in transitional cell carcinoma (TCC) ofurinary bladder. Method: Tissue samples from 13 patients with urinary bladdercancer were examined with an immunohistochemical stain for
7、 theexpression of the VEGF gene. The expression rate was compared t0 4specimens of normal bladder mucosae were thinly dissected from thetotal cystectomy specimens who had proved negative for carcinoma. Therelationship be
8、tween VEGF protein expression and clinicopathological parameters finding was statistically analyzed. The relevance of VEGFexpression in cancer formation and it growth was also observed. The results revealed significant
9、differences between normalurothelium (O%) and cancer tissue (69.2%) for the positive staining ofVEGF protein (P<0.05). With the progression of tumor grade and clinicalstaging, the positive rate of VEGF gene expression si
10、gnificantlyincreased. Expression of the VEGF gene in the invasive group wasgreater than that in the noninvasive group and significantly different Conclusion: The results revealed that expression of the VEGF geneis propo
11、rtional to the formation and progression of TCC. Therefore,abnormal expression of VEGF genes can be used as a prognostic markerin TCC of urinary bladder. Keywords: Bladder Tumor;Transitional Cells Carcinoma;Vascular End
溫馨提示
- 1. 本站所有資源如無特殊說明,都需要本地電腦安裝OFFICE2007和PDF閱讀器。圖紙軟件為CAD,CAXA,PROE,UG,SolidWorks等.壓縮文件請下載最新的WinRAR軟件解壓。
- 2. 本站的文檔不包含任何第三方提供的附件圖紙等,如果需要附件,請聯(lián)系上傳者。文件的所有權益歸上傳用戶所有。
- 3. 本站RAR壓縮包中若帶圖紙,網(wǎng)頁內(nèi)容里面會有圖紙預覽,若沒有圖紙預覽就沒有圖紙。
- 4. 未經(jīng)權益所有人同意不得將文件中的內(nèi)容挪作商業(yè)或盈利用途。
- 5. 眾賞文庫僅提供信息存儲空間,僅對用戶上傳內(nèi)容的表現(xiàn)方式做保護處理,對用戶上傳分享的文檔內(nèi)容本身不做任何修改或編輯,并不能對任何下載內(nèi)容負責。
- 6. 下載文件中如有侵權或不適當內(nèi)容,請與我們聯(lián)系,我們立即糾正。
- 7. 本站不保證下載資源的準確性、安全性和完整性, 同時也不承擔用戶因使用這些下載資源對自己和他人造成任何形式的傷害或損失。
最新文檔
- Of Tongmai Shenggu II side of the steroid-induced avascular necrosis of BGP and VEGF expression.pdf
- cloning and tissue expression of tnni3 gene in tianfu goat
- study of the artistic expression form of watercolor
- Development of Strategies for the Constitutive and Tissue Specific Expression of Cry1A(c) Conferring Resistance to Lepidoptera.pdf
- experimental study on visibility of exit signs in buildings
- An Experimental Study on Two Vocabulary Learning Strategies.pdf
- Experimental Study on Toxicity of Plumbago zeylanica Extracts.pdf
- Experimental study on visibility of exit signs in buildings.pdf
- Experimental study on visibility of exit signs in buildings.pdf
- An Experimental Study on Differentiated Instruction Mode of English Teaching.pdf
- An Experimental Study on Cooperative Learning in the ESP classroom Context.pdf
- Experimental Study on Seismic Behavior of Rectangular Hollow Pier.pdf
- ultrasonically assisted turning of aviation materials _simulations and experimental study
- An Experimental Study of Error Analysis in College English Writing Teaching.pdf
- Ultrasonically assisted turning of aviation materials _simulations and experimental study.pdf
- An Experimental Study on English Level Teaching in Senior High School.pdf
- A Cognitive Approach to the Teaching of English Prepositions-an Experimental Study.pdf
- Ultrasonically assisted turning of aviation materials _simulations and experimental study.pdf
- An Experimental Study on Inquiry Learning of High-School English Teaching.pdf
- an experimental study on reasonable content of slag in concrete c30
評論
0/150
提交評論