COX-2在急性白血病中的表達(dá)及其意義.pdf

1、青島大學(xué)碩士學(xué)位論文COX2在急性白血病中的表達(dá)及其意義姓名：鮑振華申請學(xué)位級別：碩士專業(yè)：內(nèi)科（血液病學(xué)）指導(dǎo)教師：李廣倫20070525英文摘要ExpressionandsignificanceofCyclooxygenase2inbonemarrowcellsofacuteLeukemiapatientsAbstractObjectiveToinvestigatetheexpressionandimplicationsofCOX2

2、inboneinslTowcellsofacuteleukemiapatiems，and陽VcalthepotentialpathogeneticthatCOX2inbonemalTowcellsofacuteleukemiapatientsMethods：Westernblotwasusedtom嘲I瓣theexpressionsofCox2andBc眈inboneliiRrrowcellsof67ca嘲ofacuteleukemia

3、beforeandaftertreatmentwithchemothempeutic&Results：11鷙positiverateofC0x2inbonemarrowcellsofacuteleukemiawas5373。／o(36／67)n虻COX2levelin28primarypatientswithprimaryleukemiawasO562瑚0756啦nmcmlyhigh盯thanthatincontrolgroup(p00

4、5)；andwasrcducAod蕾Do135l土o0511in雕ientsw矗hcompleteremissionnOsi蛐i矗camdifferencecomposedtocontrolgroup11聆CO)【2concentrationofthe8r印lasepatientsw熬03527士o1634and05480士0t082incompleteremissionphaseandafterreplase酬ivelythediff

5、erenceWassignificant∽005)11∞COX2levelWasre]mdtotheBcl2level(r0937，PO05)andproliferativedq蓼∞ofboneⅡ田n嘲butnotIel砒cdtothepercalesofleub洫cellsinthebonemarrowhemoglobinconcentrationandplatcletcount1ltwhiteblood∞um(WBc)ingroup

6、ofC0)(2positiveandgroupof00I)【2negativewere6930i5683(109／L)and3410a：1277(‘109／L)respectivelythedifferenceWassignificant(t=36123，P005)mLDHconcentration11groupofCOX2positiveandgroupofCo)(2negativewere35896士9903(IU／L)and295

7、25圭113440U／L)respectivelythedifferenceWassigniticant(t=21684，PO05)Conclusion：ThelevelofcoX2in1rimatypatientswithacuteleukemiawasmuchhigherthanthatincontrolgroup；itwasreducedtotheDOIImllevel觚efcompleteremissionItrisedagai

8、nwhenreplasedThelevelofCOX2waswell∞扛鏹∞ndedwithBcl2、WBC、LDHandprofiferativedegreeinbonemarrowItwassignificanttodetectCOX2concentrationinthediag螂isevah啦dis般conditionpredictmgreplaseassessingprognosisantdirectingth嗍ofacutel