超分子化學(xué)研究-化學(xué)修飾環(huán)糊精的分子識別與結(jié)構(gòu)研究.pdf

1、南開大學(xué)碩士學(xué)位論文超分子化學(xué)研究:化學(xué)修飾環(huán)糊精的分子識別與結(jié)構(gòu)研究姓名：張旻申請學(xué)位級別：碩士專業(yè)：物理化學(xué)指導(dǎo)教師：劉育19990501ABSTRACTThestudyofsupramolecularchemistryiscurrentlyasignificanttopicofchemistryandbiochemistry.Possessingfairlyrigidandwelldefinedhydrophobiccavitie

2、snaturalcyclodextrins(CDs)canbetakenasmolecularreceptorsinrecognitiontoalargevarietyoforganicinorganicandbiologicalguestmoleculestoformhostguestcomplexesorsupramolecularspecieswhichhavebeenappliedinareasofscienceandtechn

3、ologyasanexcellentmodelsystemofmimickingthesubstratespecificinteractionofenzymes.Chemicalmodificationofcyclodextrinsbringsaboutchangesonbothphysicalandchemicalpropertiesofthemandthechangeswillimprovetherecognitionofcyclo

4、dextrinseffectively.Inthisthesisaseriesofhostcompoundsderivativesofpcyclodextrinweresynthesizedandcharacterizedandtheirmolecularrecognitiontoguestmolecules(aliphaticalcoholsandnaphthalenederivatives)wasinvestigated.Furth

5、ermorewiththecrystalstructuredatawestudiedthestructureofasupramolecularassemblyconstructedbyamodifiedcyclodextrin.Thethesisincludesthefollowingmainpoints.1.Thenewprogressandimportantachievementofsupramolecularchemistrywe

6、rereviewed。2.(1)Themonotosylatedderivative6OTs(3CDwaspreparedbythereactionoftosylchloridewithpCDinalklineaqueoussolution.Atthesametimetheyieldwasimprovedbydifferenttreatmentonthecrudeproduct.(2)From6OTsRCDelevenpCDderiva

7、tivesweresynthesized.AllthesecompoundswerecharacterizedbyelementalanalysisIRUVHNMRandMSspectra.Withtheexperienceofsynthesisworkstudiesofseparationandpurificationoftheproductswerecarriedout.3.Themolecularrecognitionofgues

8、tmolecules(includingaliphaticalcoholsandnaphthalenederivatives)bythechemicallymodifiedcyclodextrinswerestudied勿thespectrofluorometricandspectropolarimetrictitrations.Theresultsobtainedindicatethatthesehostcompoundscanrec