抗腫瘤藥物樂尼安的合成及表征.pdf

1、西北大學(xué)碩士學(xué)位論文抗腫瘤藥物樂尼安的合成及表征姓名：黨文娟申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：張娟20070401西北大學(xué)碩士學(xué)位論文AbstractAsaseriousdiseaseofhumanbeingtheincidenceofUinloranditsdeathratepresentanascendingtrendinoul“country11把deathrateofmalignancyisonlyinferiortot

2、hatofheartbrainbloodvesselailmentwhichhasthehighescdeathrateamongallthediseasesWithcomplicatedcarcinogenesismechanism，theincidenceoftmnoranditsdevelopmentaresyntheticallycatlsedbymanyfactom，andmanymalignanciescannotbehea

3、ledbycurrenttherapies11圮Waditionaltherapies辨knownassurgeryradiotherapyandchemotherapyManyn洲therapiesappearwithdevelopmentofmolecularbiologyandimmunologysuch鸛geneandimmunologictherapiesHoweverallthesetherapiescannotprovid

4、eaneffectiveremedytoallkindsofturaorsThereforeit’sapressingtasktodevelop日ewtunlortherapiesLomdamme(LNO)orl—(2，ichlorobenzyl)lH—indazole3carboxylicacidadichlombenzenederivativeofindazoleacidisakindofhem∞nsifivityanficance

5、rdragLNDiseffectiveagahmanumberoftumorsincludingheadneckc硼1c％lungc觚ceLchroniclymphoblasticleukemiamalignantmelanomabreastcancerencephalomaandsoonInthispaper2HydroxyiminoNphenylacetamidewaspreparedbyusinganilineasstarting

6、materialwhichreactedwilhchloralhydratehydroxylaminehydroehlorideinsodiunlsulfatesolutionThroughexperiments，theyield(926％)wasachievedunderopth：nalreactioilconditions：moleratioofmlilinehydroxylaminehydrochlorideandchloralh

7、ydrate1：3：13，reactiontemperature98“C，reactiontime20mi也Thentheproductwas婦曲釘izedbyelementanalysisⅡ乙UV1HNl傈InadditionafarBeckmaunrearrangementandcyclizingtheproductof2HydroxyiminoNphenylacetamidereactedwithsulfuricacidtosyn

8、thesize1Hindszole一3carboxylicacidIndiazotizationtheyieldwasimpmvedfrom512％to823％throughreplacingbnannouschloridebysodiumdithionateThepurificationofproduct啪behnplementedeasilyMeanwhilethestructureoftheprodmWasconfirmedbye