清咽口含片濃縮純化工藝對(duì)乙酰哈巴苷轉(zhuǎn)移率的影響

1、清咽口含片濃縮純化工藝對(duì)乙酰哈巴苷轉(zhuǎn)移率的影響清咽口含片濃縮純化工藝對(duì)乙酰哈巴苷轉(zhuǎn)移率的影響袁淑婧范玲周琴妹1江蘇省中醫(yī)院，南京210029摘要摘要:目的目的實(shí)驗(yàn)考察濃縮純化過(guò)程中影響乙酰哈巴苷轉(zhuǎn)移率的因素，優(yōu)選清咽口含片的醇沉工藝。方法方法采用單因素考察與正交試驗(yàn)相結(jié)合的方法，以白毛夏枯草中乙酰哈巴苷轉(zhuǎn)移率及干膏得率作為考察指標(biāo)優(yōu)選醇沉工藝。結(jié)果結(jié)果優(yōu)選的醇沉工藝為：藥液濃縮至相對(duì)密度1.13，加95%乙醇至乙醇濃度為70%，醇沉?xí)r藥

2、液的溫度為60℃，冷處?kù)o置24h。結(jié)論結(jié)論優(yōu)選的醇沉工藝簡(jiǎn)單易行，適用于實(shí)際生產(chǎn)。關(guān)鍵詞關(guān)鍵詞:清咽口含片；正交試驗(yàn)；醇沉工藝；乙酰哈巴苷轉(zhuǎn)移率TheEffectofConcentrationPurificationTechnologyofQingyanBuccalTabletsonthetransferringrateofAcetylharpagideYuanShujingFanLingZhouQinmei1(JiangsuProvi

3、ncialHospitalofTCMNanjing210029)ABSTRACT:ObjectiveTooptimizethetechnologyofalcoholprecipitatingofQingyanbuccaltabletsbystudyingtheaffectingfactsofthetransferringrateofAcetylharpagideinConcentrationPurificationprocessofQi

4、ngyanBuccalTablets.MethodsAcombinedmethodofthogonaldesignsinglefactstudywasusedtooptimizealcoholprecipitatingprocesswiththeindicesoftherateofdriedextract.ResultsTheoptimalconditionswereasfollows：concentratingwaterextract

5、untilitsdensitywas1.13addingalcoholuntilconcentrationofalcoholbecomes70%，precipitating24h.ConclusionThetechnologywassimplepracticablesuitablefpracticalproduction.KEYWDS:Qinyanbuccaltabletsthogonaldesignalcoholprecipitati

6、ngtechniquethetransferringrateofAcetylharpagide清咽口含片來(lái)源于江蘇省中醫(yī)院臨床經(jīng)驗(yàn)方，由白毛夏枯草、射干、玄參等六味中藥組成，根據(jù)本制劑組成成分的性質(zhì)，對(duì)射干飲片用乙醇提取[1]，而其他五味飲片用水提1收稿日期：基金項(xiàng)目：江蘇省政府財(cái)政專項(xiàng)（省直中醫(yī)11）通信作者：周琴妹，本科，主任中藥師，主要從事中藥制劑質(zhì)量控制和新藥開發(fā)研究工作電話：02586529291，email:joy_zhou