2023年全國碩士研究生考試考研英語一試題真題（含答案詳解+作文范文）_第1頁
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1、DearEditWehavestudiedthevaluablecommentsfromyoutheassistanteditreviewerscarefullytriedourbesttorevisethemanu.Thepointtopointrespondstothereviewer’scommentsarelistedasfollowing:Respondstothereviewer’scomments:Reviewer1Com

2、ment1:inpage3line40wefedrats...“changedtoratswerefedwith...Response:Accdingtothereviewer’scommentwehavecrectedthesentence.Furthermewehavehadthemanupolishedwithaprofessionalassistanceinwriting.Comment2:page25.Thestyleofre

3、ference40isnotright(usinginitialsfthefirstnames).SincethispaperhasbeenpublishedthevolumepageNosshouldbeprovided.Response:Thankyoufyourcarefulwk.Wehaveaddedthevolumepagenumbersfreference40.Reviewer2Comment:Iwouldliketotha

4、nktheauthsftheirefftsinaddressingthecriticismswithadditionalexperiments.Theonecriticismthattheydidnotaddresswasrelatingtoenergyexpenditureasthereasonthattheanimalsonthelowcalciumdietgainedmeweight.WhileIunderstthatperfmi

5、ngthisexperimentwillnotaffecttheconclusionofthismanuIdobelievethatthispointcouldbediscussedintheDiscussionsection.Response:Thankyoufyourvaluableadvice.Basedonthepreviousrevisionwefurtheraddresstherelationshipbetweenlowca

6、lciumdietenergyexpenditureinthesectionofdiscussionaccdingtoyourthoughtfulcomments.cAMPlevelscouldhavebeenmonited.IreallydonotlikethelastsentenceintheAbstractline4750whereyoustatethat“l(fā)owcalciumdietinducedincreaseinfatmas

7、swasduetoenhancedlipogenesismediatedbyanupregulatedCaSRsignalingpathway”Yourresultshereshownosuchthingthisisacompletelyfalsestatementbasedondataherein.Crect.YoushowthathighCadietsenhancelipolysislowCadietsareantilipolyti

8、c.Youdidnotmonitlipidanabolismhereatall.Seealsoline255257lines333335ofyourMS.Response:Thankyoufyourvaluablethoughtfulcomments.Asyousuggestedthattheanabolicsideoflipidmetabolismaswellasthermogenesisissuesshouldbemonited.W

9、ereallyagreewithyourviewpoints.InthepresentstudywedidfindthatlowcalciumdietincreasedthemRNAleveloffattyacidsynthase(FAS)inwhiteadiposetissue.FurthermetheFASmRNAlevelwerealsoincreasedinadipocytesaftertreatmentwith125(OH)2

10、D3ininvitroexperiments.HowevertheincreasedFASmRNAlevelswerenotaffectedbypreventingeitherthenuclearvitaminDrecept(nVDR)calciumsensingrecept(CaSR)suggestingthatFASmightnotbeinvolvedintheCaSRpathway.InadditionwethoughtthatF

11、ASplayeditsroleinfattyacidsynthesismainlyinliverpreviously.BesidesthemanuwasrequiredtorestrictnumberoftotalwdsourpreviousfocuswasontheantilolyticroleofCaSRintheprocessoffataccumulation.SoweignedtoprovidethedataofFASmRNAl

12、evelsinthesubmittedmanu.InthenewlysubmittedmanuwehaveprovidedthemRNAlevelsaccdingtoyourhelpfulsuggestion.WehavereptedtheeffectsofdietarycalciumonUCP2mRNAlevelsinadiposetissueUCP3inskeletalmuscleinourpreviousstudies(12).T

13、huswebelievedthatlowcalciumdietledtodecreasedthermogenesisinthepresentstudy.Itwasapitythatwedidnotmeasuretheratcetemperatureinthosestudies.TheUCP2mRNAlevelsinadipocyteswereobservedtobedecreasedaftertreatmentof125(OH)2D3.

14、ThiseffectwaspreventedbyusingnVDRCaSRgenesilencingbutnotbyCaSRgeneknockdownsuggestingthatUCP2wasnotinvolvedinCaSRpathways.InthenewlysubmittedmanuwehaveprovidedtheUCP2results.Thankyoufyourcarefulreadingofourmanu.Wearevery

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