胃癌患者病情惡化時血清蛋白質(zhì)指紋表達的研究.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文胃癌患者病情惡化時血清蛋白質(zhì)指紋表達的研究姓名：梁穎婷申請學(xué)位級別：碩士專業(yè)：腫瘤學(xué)指導(dǎo)教師：裴毅20090423山西醫(yī)科大學(xué)碩士學(xué)位論文TheStudyonTheExpressionofSerumProteinFingerprintsofPatientsWithGastricCarcinomaInAggraVationCourseAbstactobject：T0deVel叩thesemmproteinfinge

2、rprintmodelofgastriccarcinomap撕entsinaggmVationcourseMethods：SELDITOF—MSandCMl0proteinchipw嬲usedtodetectmesemmproteinfinge印rintsofearlypost叩erativese砌m舶m40patientsw曲gas仃icc觚cerandpresen，emesesemmproteinfiIlge印rillts，afIe

3、rlyeallsfollow—up，a11也epatientwercdiVided砬o2伊oups：aggraVated伊oupandc撕baticgroupaCcordingt0meclinical0utconleofiImgeology(relapse0rnotandmetastasize0rnot)髓d呦礎(chǔ)Hke程(neg撕Veexpressiont0hadr0positiveeXpression)These衄protein缸ge

4、甲rintsofmreegroups(aggraVatedgroupbefore鋤daRerfollow—up，ag野w咖dgroup觚dc撕b撕cgroupbeforef0110w—up，aggraVatedgroup鋤dca切l(wèi)batic蓼oup疵rfollowup)werecoInparedbyBioma呔erWizardSo腑areandmeag粵aVatedproteomicfinge印訂ntmodelofgastriccar

5、ciIlonlaweredevelopedbyBiomarkerPattemSo仃wareResults：Afterfollowup，23casesof40casesdeVel叩edag黟av撕onandl7casesof40c硒espostope訓(xùn)Vegasticcarcinomapatientsgotrelie￡(1)ComparedwithaggraVatedgroupbefore卸Idafb玎follow—up，merewere

6、10significantdifferentialproteinfingerprints，鋤ongt11etotal，mesensiti啊夠鋤dspecific毋of3proteinfmge印血ts(M／ZValueswere6935，2687，11825)w嬲86957％(20／23)鋤d91304％(21／23)，吐leaCcuracyw嬲8913％(4l／46)2687and“825wereupregulationfinge印血t

7、s，6935wasd(wnregulationjfinge印rint(2)C伽叩aredwithag伊avatedgroupandca訕aticgrollpbef0Ief0110wup，therewe托7si薩i6c粗tdi‰婦lpr咖infmge印血ts，Among也etotal，thesensitiV匆andspecific毋ofmed0、釉一reglllationproteinfinge叩rints(M億Valuesw嬲5632)

8、was94118％(16／l7)觚d7826l％(18／23)，theaccul佻yw嬲85％(34／40)(3)Comparedw池aggraVatedgroupandca曲aticgroupaRerf0110wup，therewere37si鰣6c雒t砌睹re確alproteinfing唧ri幽，thesensitiVi哆andspecifici夠ofmeup—regulationproteinfmge印rin“M／ZValuesw