三血管序列切面篩選與診斷胎兒心臟病的臨床研究.pdf

1、Objective this study is to investigate the clinical significance ofthree-vessel subsequence views in prenatal diagnosis of fetal congenitalheart disease.
　　 Methods from April 2006 to April 2010,three-vessel subseque

2、nceviews of 2229 normal fetuses and 231 fetuses with congenital heartdisease were obtained with Sequoia 512,Voluson 730 and E8 colorDoppler ultrasonographic diagnostic system.The diameters of pulmonaryartery,ascending ao

3、rta and superior vena cava were measured onthree-vessel view and ratio of pulmonary artery/ ascending aorta,ascending aorta / superior vena cava were calculated.
　　 Results The diameters of pulmonary artery,ascending

4、 aorta and superiorvena cava include 2.5％percentile,5.0％percentile,95.0％percentile,97.5 ％percentile were significantly differential among gestation groups(p<0.05)and increasing with gestation week and have straight linec

5、orrelation with the coefficient correlation being 0.92,0.90 and 0.88respectively(p<0.05).ratio of pulmonary artery/ascending aorta is stablefrom 18 gestation week to 38 gestation week and have no straight linecorrelation

6、(p>0.05),the ratio of ascending aorta / superior vena cava wasdowntrend with gestation week,but statistics showed no significantlydifferential(p>0.05).Of 231 consecutive fetuses with CHD,169 wereshown to have at least on

7、e abnormality on the three-vessel subsequenceviews,a detection rate of 73％.When septal wall defects were excluded,the detection rate increased to 91％.All cases of transposition of greatarteries(TGA),double outlet right v

8、entricle(DORV),aortic stenosis,pulmonary stenosis,truncus arteriosus and ductal aneurysm showedabnormal three-vessel subsequence views.Additionally,some defects hadseveral abnormalities visualized at the three-vessel sub

9、sequence views.
　　 Conclusion This prospective descriptive study demonstrates that thethree-vessel subsequence views has high detection rate in identifyingclues for the presence of CHD,especially when excluding septa