微乳介質(zhì)中偶聯(lián)反應研究.pdf

1、南京理工大學博士學位論文微乳介質(zhì)中偶聯(lián)反應研究姓名：蔣建中申請學位級別：博士專業(yè)：應用化學指導教師：蔡春20070601AbstractAmieroemulsionisathermodynamicallystable，isotropic，opticallytransparentsolutionconsistingofwateroilandasurfactamMieroemuisioncouldcosolubilizegreatamoun

2、tsofhydrophilicandhydrophobiccompounds，whichwouldresolvethewell—knownsolubilizationproblernsTheinterestofmieroemulsioninorgauiesynthesisrelatestotheirextremelylargeinterfacialareas，providingspecificrateenhancementandover

3、comingreagentineompadbilityMicroemulsionhavenanomemesizeofdroplets，whichareparticularlysuitablellano—reactorsfororganicreactionsInpreviousreportsonmicroemulsion，mostofstudiesconcemedtheuseofmicroemuisionasreactionmediumi

4、norganicsynthesisThus，thedevelopmentofnewroutesOnapptyingmicroemulsioninmodemorganicsynthesisisconsideredtobeoneofthemostchallengingfieldsThiSdissertationfocousedOncouplingreactionsinmicroemulsionsWefoundtheTXl0／heptsneB

5、outanol／water／propyleneglycol(PG)microemulsionsWerenotonlythereactionmediumforligund—freecouplingreactions(SonogashiraHeckandUllmannreactions，eta1)’butalseducingagentsforthecouplingreactionsTXl0／heptane／butanol／water／PGm

6、ieroemulsionswerepreparedfitsinsensitivemieroemutsionwhichcou／dbestable戤3080。C’stemperaturerangeand弘心，3M’sbaseconcentrationrange，andtheinsensitivemicroemulsioncouldbestableatthecourseofthecouplingreactionsNanosizedPdofor

7、thecouplingreactiOIlScouldbeinsituformedinthemicroemulsionswithoutotherreducingagentsThemieroemulsionscontainingin—situformednanoPdowereappliedtotheligand—freecouplingreactions髓eeffectofreactionparameterswerediseussedThe

8、resultsindicatedthattheaqueousphaseconcentrationbaseconcentrationandtemperatureplayedkeyroleonthereactionIodobertzenewasconvertedtothecorrespondingtolanequantitativelywithin2rainTherefore，TX100／heptane／butanol／water／prop

9、ytene甜ycolmicroemulsionscontaininginsituformedpalladiumnanoparticleswereveryefficientcatalystsystemsforligand—freecouplingreactions11圮heterogeneouscatalysts(Pd／c、Pd(NH3)42fNaY)couldcatalyzeligand—freeSonogashira、Heck、Suz

10、uki、UllmannreactionsExcellentresultofchlorobenzeneinPd／CcataIyzedUllmannreaetioncouldbeachievedinmicroemulsionswithoutotherreducingagentsTheeffcctofreactionparametersonthesupportedPd—catalyzedcouplingreactionsinthemicroe