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1、EfficacysafetyofcolchicinefpericarditispreventionSystematicreviewmetaanalysisTopics:PericardialDiseaseAuths:MassimoImazioAntonioBrucatoDavideFnoSilviaFerroRiccardoBelliRitaTrincheroYehudaAdlerHeart201298:10781082.doi:10.
2、1136heartjnl2011301306.HeartEdit’schoiceBackgroundRecurrentpericarditishasbeenreptedin25%to50%ofcases(12)itisoftenthemosttroublesomecommoncomplicationofpericarditis(3).Recurrencesareoftencauseofreadmissionsrepetitionofdi
3、agnostictests.Thuspreventionofrecurrencesisamajtherapeuticgoaltoimprovethequalityoflifeofpatientsreducemanagementcosts.Empiricantiinflammatytherapiesaremainstayofmedicaltherapybuthavenotbeenproventobeefficaciousfthepreve
4、ntionofrecurrenceswiththepossibleexceptionofcolchicine(46).Shareonlinkedin1AimmethodsAsystematicreviewwasperfmedtoassesstheefficacysafetyofcolchicinefpericarditisprevention.Romisedclinicaltrialsonpharmacologicalpreventio
5、nofpericarditiswereincluded.PotentiallyrelevantstudiespublisheduptoDecember2011weresearchedinBioMedCentraltheCochraneCollabationDatabaseofRomisedTrials(CENTRAL)ClinicalTrials.govEMBASEGoogleScholarMEDLINEPubMedScopus.The
6、PubMedsearchwasperfmedwiththeterm‘pericarditis’‘colchicine’.Recent(2005later)conferenceproceedingsfromtheAmericanHeartAssociationAmericanCollegeofCardiologytheEuropeanSocietyofCardiologywereelectronicallymanuallysearched
7、.Searcheswerenotlimitedbylanguagesexage.Inadditionreferencesofretrievedstudieswerescannedfadditionalunpublishedstudies.MainresultsFromtheinitialsampleof127citationsfivecontrolledclinicaltrialswerefinallyincluded(795patie
8、nts)arereptedinthefollowingtable.Threestudiesweredoubleblindromisedcontrolledtrials(79)twostudieswereopen1.ImazioMBobbioMCecchiEetal.Colchicineinadditiontoconventionaltherapyfacutepericarditis:resultsoftheCOlchicinefacut
9、ePEricarditis(COPE)trial.Circulation2005112:201216.2.ImazioMBobbioMCecchiEetal.Colchicineasfirstchoicetherapyfrecurrentpericarditis:resultsoftheCE(COlchicinefREcurrentpericarditis)trial.ArchInternMed2005165:198791.3.Imaz
10、ioMSpodickDHBrucatoAetal.Controversialissuesinthemanagementofpericardialdiseases.Circulation2010121:91628.4.ImazioM.Pericardialinvolvementinsystemicinflammatydiseases.Heart201197:188292.AdlerYFinkelsteinYGuindoJetal.Colc
11、hicinetreatmentfrecurrentpericarditis:adecadeofexperience.Circulation199897:21835.5.ImazioMBrucatoATrincheroRetal.Colchicinefpericarditis:hypehopeEurHeartJ200930:5329.FinkelsteinYShemeshJMahlabKetal.Colchicineftheprevent
12、ionofpostpericardiotomysyndrome.Herz200227:7914.6.ImazioMTrincheroRBrucatoAetalCOPPSInvestigats.COlchicinefthePreventionofthePostpericardiotomySyndrome(COPPS):amulticentreromizeddoubleblindplacebocontrolledtrial.EurHeart
13、J201031:274954.7.ImazioMBrucatoACeminRetalCPInvestigats.COlchicinefrecurrentpericarditis(CP).Aromizedcontrolledtrial.AnnInternMed2011155:40914.8.MaischBSeferovicPMRisticADetalTaskFceontheDiagnosisManagementofPericardialD
14、iseasesoftheEuropeanSocietyofCardiology.Guidelinesonthediagnosismanagementofpericardialdiseases.EurHeartJ200425:587610.ThecontentofthisarticlereflectsthepersonalopinionoftheauthsisnotnecessarilytheofficialpositionoftheEu
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