(e)β芳基β酰胺基丙烯酸酯的不對(duì)稱氫化反應(yīng)研究

1、蘇州大學(xué)碩士學(xué)位論文（E）β芳基β酰胺基丙烯酸酯的不對(duì)稱氫化反應(yīng)研究姓名：劉曉丹申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：張松林20090501EnantioseleetiveHydrogenationof夕arylsubstituted(E)pac—et—y—la—m—i—no—a—c—ry—la—t—eAbsttactEnantioselectiveHydrogenationof]Arylsubstituted(E)pAeetyla

2、minoacrylateAbstractEnantiomericallypurepaminoacidsareimportantchiralbuildingblocksforthesynthesisofflpeptides，fllactamantibiotics，andmanyotherimportantchiraldrugsForthesereasons，enantioselectivesynthesisofflaminoacidsha

3、sattractedextensiveinterestRecentlythesynthesisprocedureofparyl—substituted④i伊acetylaminoacrylatehasbeenprovedwrongAfterconsultingalotofliteratures，thispapermainlyrealizedthesynthesisofparylsubstituted㈣毋acet)rlaminoacryl

4、ate，andwealsostudiedthehydrogenationofparyl—substituted④一p—acetylaminoacrylatescatalyzedbyRu(OCOCH3)2[(R)BrNAP]1Weimprovedthesyntheticmeth&tofflaryl—substituted㈣毋acetylaminoacrylates2Wehaveinvestigatedthehydrogenationof／

5、：arylsubstituted固毋acetylaminoacrylatescatalyzedbyRu(OCOCH3)2[(R歸INAP]Theinfluenceofthereactionsolvent，thepressureofH2，reactiontemperatureandtheloadingofcatalystonthereactionwasstudiedindetailTheresultshowedthatRu(OCOCn3h

6、[(R)一BINAP]hasgoodcatalyticactivitytothisreaction，buttheenantioselectivityofcatalystsWasmoderate，whichupto80％ee3Westudiedthereactionofallylsamariumbromidewithqc#dihaloketonesTheproductofthisreactionisatypeofmultifunction

7、alcarboncompounds：僅一hydroxy—aallyl—aldehydeacetalsThismethodhastheadvantageoftakingplaceinonepot，atroomtemperatureandinhi曲yieldsKeywords：]／aminoacids；catalytichydrogenation；allylsamariumbromide；multifimctionalcarboncompo