GLP-1對STZ誘導AD模型保護作用.pdf

1、山西醫(yī)科大學碩士學位論文GLP1對STZ誘導AD模型保護作用姓名：高穎申請學位級別：碩士專業(yè)：神經(jīng)生物學指導教師：李琳20090318山西醫(yī)科大學碩士學位論文AbstractPropose：ToinvestigateGLP一1’SprotectionfunctiontoADanimalmodelinducedbySTZThestudyaimis：(DeflectofGLPlonbehaviorofratstreatedbySTZ；(2)

2、effectofGLP一1onApinserumandbrainofratstreadedbySTZMethod：MaleWisterratswerefedforaweekandtheweakerones，whichhaveabadappetiteorlostweightquicklywereexcludedThen30qualifiedratswereleftafterthechoiceofMorriswatermaze，throug

3、hwhichtheDown’Ssyndromes(theaverageofincubationperiodisOVer50s)andtheoneswhichdidn’tswimwellwereexeludedThe30qualifiedratsweredividedintothreegroups：blackcomparisongroup，ADmodelgroupandGLP—lprotectedgroupTherearel0ratsin

4、eachgrouprespectively111eratsinADmodelgroupwereinject。d10％STZthroughhead，andGLPIgroup10％STZandGLPl，whiletheblackcomparisongrouponlyPhysiologicalSaline111ewoundwasmanagedtreatedwithantibiotic7days，14daysand21daysrespeetiv

5、elyaftertheoperationveinbloodoftheratswasdrawandthelevelofsemmwastestedbyunsaturatedradioimmunoassayThebehavioroftheratsbeforeand21daysaftertheMorriswatermazetestwerecomparedAfterpuRingthemtstodeaththechangesofAlBintheir

6、brainorganizationweretestedResults：(1)Theavoidinglatcntperiodofrats仃eatedbySTZWasdelayedascomparedwithcentrelratsGLP1reversedthedamageofSTZtoshortenlatentperiodofratscomparedwitlltheratstreatedbySTZ(2)Theratsofcentrelswa

7、mmoreintheareawheretheplatfcIrlnhadinstalledcompared誦tlltheratstreatedbySTZTheratstreatedbyGLP1swammoreintheareawheretheplatfoHnhadinstalledcomparedwiththeratstreatedbySTZ(3)SerumApofratstreatedbySTZwasobviouslyelevateda

8、scomparedwithcontrolmtsandtheratstreatedbyGLP1(4)Moreimmunestainingneuronsweres嘲inthebrainofratstreatedbysTZascomparedwithcontrolratsandtheratstreatedbyGLP1Conclusion：GLPlimprovedbahaviordamagedbySTZ，decreaded∞r(nóng)ulmApindu