直腸癌HER-2、COX-2和血清CEA表達(dá)及三者之間的相關(guān)性研究.pdf

1、溫州醫(yī)學(xué)院碩士學(xué)位論文直腸癌HER2、COX2和血清CEA表達(dá)及三者之間的相關(guān)性研究姓名：潘貽飛申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：腫瘤學(xué)指導(dǎo)教師：張?bào)泸?0080501ExpressionofHER2、COX2andserumCEAinrectalcarcinomaandcorrelationbetweenthemAbstractUbjective：TostudytheexpressionofHER一2、COX一2andserumCEAinrec

2、talcarcinomaandcorrelationbetweenthem，exploretheirclinicalsignificanceMethods：TheproteinexpressionofHER2andCOX2wereexaminedbvimmunohistochemicalstainingin50casesofrectalcarcinoma、15casesofadenomaand15casesofnormaltissueT

3、heserumCEAvaluesof50casesrectalcarcinomawereexaminedbychemiluminescentimmunoassaybeforeoperation，bothcorrelationbetweenHER一2、COX一2、serumCEAandpathologicfeatureandcorrelationbetweenHER一2、COX一2andserumCEAwereanalysesedbySp

4、earmanResults：ThepositiveratesofHER一2innormaltissue、adenomaandrectalcarcinomawereO％、0％、6％，respectively，therewasnodifferencebetweenthem(P005)：whilethepositiveratesofCOX一2increasedfromnormaltissue(133％)、adenoma(400％)torect

5、alcarcinoma(840％)，(P005；r=0074，P005)，ButthepositiveexpressionofCOX2wascorrelatedwithlymphnodesmetastasisandDukes，stage(P005)；TheserumCEAwasco玎elatedwithDukes，stage(PO05)。THEserumCEAwaspositivelycorrelatedwiththeproteinex

6、pressionofCOX2(FO292，P005)Conclusion：1ThepositiveproteinexpressionofHER2inrectalcarcinomaisvery10wanddoeSnotcorrelatewithCOX2、serumCEAHER2doesnotplayanimportantr01einthedevelopmentandprogressionofrectalcarcinomaanddoesno