PAR-2、β-catenin和COX-2在胃腺癌中的表達(dá)及相關(guān)性研究.pdf

1、蘇州大學(xué)碩士學(xué)位論文PAR2、βcatenin和COX2在胃腺癌中的表達(dá)及相關(guān)性研究姓名：俞敏申請學(xué)位級別：碩士專業(yè)：病理學(xué)與病理生理學(xué)指導(dǎo)教師：馮一中20100601英文摘要PAR2、βcatenin和COX2在胃腺癌中的表達(dá)及相關(guān)性研究IIExpressionofPAR2、cateninCOX2inGastricAdenocarcinomatheCrelationAnalysisAbsractObjective：Toanalyzet

2、hesignificanceofPAR2cateninCOX2inthecarcinogenesisprogressionofgasticadenocarcinomatostudytheexperimentalfoundationoftheprognosisevaluation.Methods：ImmunohistochemicalSPmethodwasusedtodeterminetheexpressionofPAR2cateninC

3、OX2in63casesofgastricadenocarcinoma19casesoflowgradeintraepithelialneoplasia20casesofnmalgastricmucosaltissuestherelationsbetweentheexpressionofthemclinicopathologicalfeaturessurvivalratethecrelationbetweenPAR2cateninCOX

4、2wasanalyzed.Results：（1）ThepositiveratesofPAR2ingastricadenocarcinoma、inlowgradeintraepithelialneoplasiainnmalgastricmucosaltissueswere47.6%、21.1%、10%theabnmalexpressionratesofcateniningastricadenocarcinoma、inlowgradeint

5、raepithelialneoplasiainnmalgastricmucosaltissueswere55.6%、31.6%、0%thepositiveratesofCOX2ingastricadenocarcinoma、inlowgradeintraepithelialneoplasiainnmalgastricmucosaltissueswere68.3%、42.1%、30%.（2）TheexpressionofPAR2incar

6、cinomatissuewascloselycrelatedwithdepthofinfiltration（P＜0.05）butnotwithagegenderdifferentiationdegreelymphnodemetastasisTNMstagestheabnmalexpressionofcateninwascloselycrelatedwithdifferentiationdegreedepthofinfiltrationl

7、ymphnodemetastasisTNMstages（P＜0.05）butnotwithagegendertheexpressionofCOX2wascloselycrelatedwithdepthofinfiltrationlymphnodemetastasisTNMstagesbutnotwithagegenderdifferentiationdegree（P＜0.05）.（3）AccdingtothemethodofSpearm