超聲光散射成像對乳腺腫瘤的診斷價值及其影響因素.pdf

1、東南大學(xué)碩士學(xué)位論文超聲光散射成像對乳腺腫瘤的診斷價值及其影響因素姓名：趙天慧申請學(xué)位級別：碩士專業(yè)：影像醫(yī)學(xué)與核醫(yī)學(xué)指導(dǎo)教師：張熾敏20090501東南大學(xué)碩上學(xué)位論文EnglishAbstractTITLE：DiagnosticValueofUltrasoundGuidedDiffuseOpticalImagingonBreastCanceranditsInfluencingFactorsCANDIDATE：ZHAOTianhuiS

2、upervisor：ZHANGChirainFRoM：SoutheastUniversityObjective：(1)Toelucidatetherelationshipbetweenmaximumhemoglobinconcentration(MHC)detectedbyUltrasoundGuidedDiffuseOpticalImagingsystemandhemoglobinconcentrationinsimulatedbre

3、asttumor；(2)ToclarifythediameterandthedepthhowtoimpactonMHC；(3)ToevaluatethediagnosticvalueofUltrasound—GuidedDiffuseOpticalImagingonbreasttumorandanalysisitsinfluencingfactorsMethods：(1)ExperimentalstudyDifferenthemoglo

4、binconcentration(25Itmol／L、50lamol／L、100lxmol／L、150pmol／L、200pmol／L、400lamol／L)suspensionsofredeellwerepouredintosilicagelballoonstomakesacculiindifferentdiameter(5mm、10mm、15mm、20mm、25mm)thenthesesacculiwerefixedonebyone

5、inoneoftwocontainersfilledwithO6％intralipidemulsionThesesacculiweredetectedbyUltrasoundGuidedDiffuseOpticalImagingindifferentdepth(5ini／1、l0mm、15inl／1、20rnrn、25nlnl)，respectivelyTherelationshipsbetweenhemoglobinconcentra

6、tion，diameterordepthofsacculusandMHCofsacculuswereanalysed；(2)Clinicalstudy84consecutivewomenwitll88breastmassesfromApril2007toMay2008werescannedbyUltrasoundGuidedDiffuseOpticalImagingbeforeoperation，thediameteranddeptho

7、fbreastmassweremeasuredsimultaneouslyThesensitivityspecificityofUltrasoundGuidedDiffuseOpticalImagingonbreastCanCerwerecaculatedbasedonhistologystandardResults：(1)ArelationshipofthenaturallogarithmexistedbetweenMHCandhem

8、oglobinconcentrationinsacculus(MHC=alnsacculushemoglobinconcentrationb)；但)Ifotherfactorswerenotchanged，MHCincreasedlinearlywiththeaugmentofsacculusdiameter(MHC=axsacculusdiameterb)；(3)W11eIlthehemoglobinconcentrationandt

9、hesacculusdiameterwerefixed，MHCdecreasedlinearlywiththeaugmentofsacculusdepth(MHC=axsacculusdepthb)；(4)ThepredictivevalueofMHC=一1325404xlnsacculushemoglobinconcentration93xsacculusdiameter57xsacculusdepth；(5)Thesensitivi

10、tyandthespecificityofUltrasound—GuidedDiffuseOpticalImagingonbreastcancerwere861％and788％，respectivelyT11eaverageMHCofinvasiveductalcarcinoma(210499)I_tmol／Lwashigherthanthatofmammaryadenosis(114490)lamol／Lorbreastfibroad

11、enoma(78440)pmol／Lp005Tlemisseddiagnosisandmisdiagnosiswererelatedtothepathologicaltype，thesizeorthedepthofbreastmassConclusion：UltrasoundGuidedDiffuseOpticalImaglngCandistinguishbenignbreastmassfrommalignantbreastmassin