月橘烯堿和Murrapanine類似物的合成及生物活性研究.pdf

1、河南大學碩士學位論文月橘烯堿和Murrapanine類似物的合成及生物活性研究姓名：胡衛(wèi)東申請學位級別：碩士專業(yè)：分析化學指導教師：?？顺躺?0050501AbstractIndoleanditsderivativesbroadlyexistinthenatureIndolealkaloidsarethemaximumalkaloidswhichhavebeenfoandIndolederivativesareattentivebe

2、causeoftheirmanybiologicalactivities，andtheindolylgroupisincludedinmanyclinicalptmrmaceuticalsOntheotherhand，NonsteroidaleantiinflammatorydrugsfNSAIDs)arewidelyusedinthepeople’Sdailylifeforthetreatmentoffever，pain，andinf

3、lammationassociatedwitharthritisandrheunlatismHoweverthetraditionalNSAIDsusuallyhaveserioussideeffectsingastrointestinaltractandrenaltoxicityprimarilySoitisimportanttodevelopnewNSAIDswithstrongactivitybutlowsideeffectsFr

4、omtheabovementioned，wehavetriedtodesignandsynthesizesomenovelindolealkaloidsinordertoinvestigatetheirbiologicalactivitiesIntheliteraturereviewthethesisdiscussestheresearchonthepharmacologicalactivitiesandthesynthesisstra

5、tegyofindolederivativesbrieflyintroducesmechanismsofactionandthefrontierofNSAIDsinrecentprogressoftheresearch，anddescribesthecharacteristicsofsometypicalNSAIDsSubsequentlytheintentionandgoalof011I“workisreposedbrieflybas

6、edonsomefieldlistedaboveThesynthesisofYuehchukeneandMurrapanineAnaloguesWehavesynthesizedindole一3一aldehyde2byindolewithDMFandPOCL3，2wastosylatedtoyield1tosyl—indole一3aldehyde4thencondensedwithacetonetogive1Tosyl3(1methyl

7、vinylketone一3)indole5[or2condensed麗tllacetonetogive3(1methylvinylketone一3)indole3，3Wastosylatedtoyield5]Thekeyintermedidte1Tosyl3一(1methyl1，3一vinylallyl)indole6wasobtainedbyWittigreactionofn，B—unsaturatedketone5withethyl