人乳頭瘤病毒與宮頸病變的相關(guān)研究.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文人乳頭瘤病毒與宮頸病變的相關(guān)研究姓名：牛淑芳申請學(xué)位級別：碩士專業(yè)：婦產(chǎn)科指導(dǎo)教師：吳素慧20070420山西醫(yī)科大學(xué)碩士掌位論文TheresearchofthecorrelationbetweenhuamnpapillomavirusandcervicallesionsAbstractobiectives：Humanpapillomavirus(HPV)especiallyhighriskHPVinfectio

2、nsincreasetheriskofdevelopingcervicallesionsCervicalcanceristhesecondc盯cmomaintheworldnlemordilityofcervicalcallccrofShanxiterritoryishigherthan0thefSThepurposesofourresearchweretoinvestigatethecorrelationbetweentheposit

3、iverateofHPVgenetypesandtheseverityofcervicallesionsinShanxiterritoryMethods：WecollectedelinicaldataandcervicalexfoliatedcellsbeforetreatmentinFirstAffiliatedHospitalwitIShanxiMedicalUniversityandShanxiProvinceCancerHosp

4、italHybridCaptureⅡwasemployedtodetectthepositiverateofhighriskHPVflowthroughHybridizationwasemployedtodectetthegenetypesofHPVincervicallesionsResults：ThepositiverateofHPVtestincervicitis，CINI，CINII，CINIIIandcervicalcance

5、rwere4375％，6333％，9200％，9313％，9592％，respectivelyThemedianHPVDNAloadsofcervicitis，CINI，CINII／IIIandcervicalCanCerwere071，510，11382，12623，respectivelyThemostcommongenetypesincervicallesionswe∞HPV16，18，52，58，33，31Thepositive

6、rateofHPVl6washigherthanothertypesThemostcommongenetypesincervicalsquamousepitheliumc卸cinomawereHPVl6，58，52，66，33，11，68，31，18ThepositiverateofHPVl8waslowerthanothersincervicalsquamousepitheliumcarcinom亂HPV5258weretheseco

7、ndgenetypesincervicalsquamousepitheliumcarcinomaThepositiverateofHPV66，68werehigherincervicalsquamousepitheliumcarcmomaThepositiverateofmultiplicitasgenetypesinfectioninnormal，cervicitis，CINI，CINII，CINIIIandcervicalCanCe

8、rwere190％，358％，459／0，549％，608％，702％，respectivelyConelusions：1HighriskHPVinfectionisanimportantfactorindevelopingcervicalcancelanditsprecursors111eviralloadofHPVDNAcannotsignifythedevelopmentofcervicaldiseases2Themostcomm