脾酪氨酸激酶（Syk）在宮頸癌中的表達及其臨床意義.pdf

1、青島大學(xué)碩士學(xué)位論文脾酪氨酸激酶（Syk）在宮頸癌中的表達及其臨床意義姓名：李雪梅申請學(xué)位級別：碩士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：趙淑萍20080517AbstractExpressionofSykincervicalcarcinomaanditsclinicalsignificanceObjectiveToexploretheexpressionsandtheirclinicalsignificanceofspleentyrosinekin

2、ase(Syk)proteininhumancervicalcarcinomaMethodsPV6000immunohistochemistrywasappliedtodetecttheexpressionsofSykproteinin46cervicalcarcinoma15chronicinfammtionandnormalcervicaltissuesToanalyzedofthelevelsofSykproteininaconj

3、unctionwiththeclinicalfeaturesofcervicalcarcinomaResultsThepositivestainingofSykproteinmainlylocalizedinthecytoplasm，distributeddiffuselyandhighlyintensityexpressioninthenormalcervicaltissueandchroniccervicitistissue，but

4、theexpressionofSykproteinwasweakerincervicalcancerTheexpressionofSykproteinincervicalcancer，chroniccervicitisandnormalcervicaltissuedifferently(矛=13184，P005)TherewasnosignificantrelationshipbetweenthelevelsofSykproteinex

5、pressionwiththepatients’ages砰=0869，PO05)，pathologicaltypes(x3=0269，P005)andtheclinicalstage(矛=0253，P005)ininvasivecarcinomaofcervix，ButthelevelsofSyk’proteinexpressionwassignificantassociatedwiththethedifferentiationoftu

6、morhistology(Z=4749，P005)，lymphnodemetastasis(Z=5828，P005)andtheinvasionofdeepmuscularlayer(X2=3982，P005)ConclusionsTheexpressionofSykproteinincervicalcancerchroniccervicitisandnormalcervicaltissuewasdifferentTherewasnod

7、ifferencebetweennormalcervicalandchroniccervicitistissueonSyk—proteinexpressionThelowerexpressionofSykmayplayanimportantroleingenesis／invasiveandmetastasisofcervicalcarcinomaChroniccervicitismaynotberiskfactorsforthegene

8、sisofcervicalcancelDetectionofSykproteinmaybeusedasreferencemarkersforjudgingprognosisofpatientswithcervicalcarcinomaPostgraduatestudent：XuemeiLi(gynecology)DirectedbyProfShupingZhaoKeywords：spleentyrosinekinase；cervical