肝支持系統(tǒng)治療肝衰竭.pdf

1、Despite the progress made in the intensive care treatment，liver failure is stillassociated with a high mortality，liver transplantation is the effective form oftreatment that allows better patient outcome. Nonetheless，the

2、re is organshortage and there is a need for liver support devices (LSD) that can effectivelymanage liver failure to bridge waitlist patients to transplant or regenerationwhenever possible. At present，the development

3、of LSD has been approached in two ways.Artificial LSD is based on detoxification functions using membranes andadsorbents which can remove the putative toxins associated with liver failure.The other is bioartificial LSD，a

4、re based on the use of living hepatocytes witheither human hepatocytes or porcine hepatocytes which aim to provide thesynthetic functions of the normal liver. However，in clinical practices often use acombination of devic