抗仔豬腹瀉中藥口服液的制備及質(zhì)量標(biāo)準(zhǔn)研究.pdf

1、東北農(nóng)業(yè)大學(xué)碩士學(xué)位論文抗仔豬腹瀉中藥口服液的制備及質(zhì)量標(biāo)準(zhǔn)研究姓名：孟倩申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：基礎(chǔ)獸醫(yī)學(xué)指導(dǎo)教師：李繼昌20070620StudyonthePreparationandQualityStandardofThetraditionalChinesemedicineoralLiquidAgainstPost—weaningSwineDiarrheaAbstractPostweaningswinediarrheaisacom

2、monprobleminpigfarms，seriouslyinfluencingpiggrowth，evencausingtodie，caminggreatdamagetopigraisingindustryisoneofthemostimportantfactorsthatrestricttheeconomydevelopmentofpigraisingindustryInthisstudyaccordingtotheChinese

3、veterinarymedicinetheoriesandtheetiopathogenisis，cardinalsymptomandt11epathopeiesismechanism，twelveChinesetraditionalmedicinesRadixPulsatillae，RhizomaCoptidis，CortaPhellodendri，RadixScutellariae，RadixAs加agaBRaidixPaeonia

4、eAlbaRadixAngelicaeSinensis。RadixAucklandiaeRh垃Ⅲ4AtractylodisMacrocephalae，PoHaFructmCrataegi，RadixGlycytthizaeworechoosedtodothebacteriostasisexperimentinvitroTheusedstralaswereEcoli07s，EcoliO2la，EeoliOz，hogcholeramlmon

5、ella。TheantibacterialactivitiesoftheChinesetraditionalmedicinesagainstfourstrainsweretestedbydoublingdilutionmethodinvitro，andtheMICswereme∞uredThenfiveChinesetraditionalmedicineswhichhadbetterantibacterialactivitieswere

6、choosedtopreparethreedifferentcompounds，andalsotheMICsofthecompoundpreparationweremeesuredFinallythebestcompoundwasconsfitudedbyRh括omaCoptidisRadixSeutellariaeRadixGlyeytthizae，RadixAucklancliaeFructusMume1n恤aspcctofprep

7、aringtechnologytheoralliquidwasselectedunitedwithpathogenyclinicalod，doseetc11“extractingmethodswereselectedaccordingtotheeffectivecmponentspharmacologicalactjoILphysicalandchemicalpropertyetcRhizomaCoptidiswereextracted

8、byalcohol，theoptimumextractionconditionwasinvestigatedwithorthogonaldesignmethodbydeterminingthecontentofberberineRadixScutellariaewasdecoctedbywatertheoptimumpreparingcraftwasgainedbyorthogonaltesttakingthecontentofbaic

9、alinasstudyindexes：RadixGlycytthizaeRadixAucklandiaeandFructusMumeweredecoetedbywatertheoptimumpreparingcraftwasgainedbyorthogonaltesttakingthecontentofGlycyrrhizinasstudyindexes；Theresultsshowedthattheoralliquidpreparat

10、iontechnologywas：Rh拓omaCoptidisWereextractedby70％alcohol，extracting2times，every15hours，adding12timesamountofthe70％aleoh01RadixScut￡llariaewasdecoetedby16timesamountofwaterextracting2timesevery15hoursneOthersweredecoctedb