38例外周T細(xì)胞淋巴瘤行外周血干細(xì)胞移植的臨床預(yù)后分析.pdf

1、軍醫(yī)進(jìn)修學(xué)院解放軍總醫(yī)院碩士學(xué)位論文38例外周T細(xì)胞淋巴瘤行外周血干細(xì)胞移植的臨床預(yù)后分析姓名：張松松申請學(xué)位級別：碩士專業(yè)：血液病學(xué)指導(dǎo)教師：于力；趙瑜20120523——軍醫(yī)進(jìn)修學(xué)院碩士學(xué)位論文——————————————————————————————————_二_二二二二二_———一Long。termoutcomesofPeripheralBloodStemCellTransplantationfor38PatientsWith

2、PeripheralTcellLymphomaAbsractObjective：Toinvestigateclinicalcharacteristics，response，outcome，andprognosisofperipheralbloodstemcelltransplantation(PBSCT)forpatientswithperipheralTcelllymphoma(PTCL)Methods：Weretrospective

3、lyanalyzedtheefficatyofPBSCTin38patientswithpathologicallyconfirmedPTCLfromOctober1994toOctober2010ingeneralhospitalofPLAKaplanMeiermethodswereappliedinsurvivalanalysisandtheCOXregressionmodelwasappliedinmultivariateanal

4、ysisThereweretenclinicalparametersappliedincludingage，sex，extranodalinvolvement，Bsymptoms，serumlacticdehydrogenase(LDH)internationalpronosticindex(IPI)，ECOGscore，AnnArborstage，diseasestatuspretranslantandthetypeofPBSCTRe

5、sults：ThepatientswithPTLCsurvivedatamedianof24monthsposttransplantInourstudythe2yearoverallsurvival(os)was46％，andthe5yearOSwas34％afterallledianfollowupofmonthsThepatientswhoreceivedalloPBSCThadahigherNonrelapsemortality(

6、NRM)，buttheycouldacievefllongerdiseasefreesurvivalSurvivalanalysiswithKaplanMeiermethodshowedthediseasestatuspretransplant，Bsymptoms，serumLDH，ECOGscore，PITscorewereallprognosticfactorsofposttransplantOSDiseasestatuspretr

7、anslantistheonlyprognosicfactorofalloPBSCTConclusion：ForrefractoryorrelapsedPTCLpatients，whenconventionalchemotherapyCanachieveacompleteremission(CR1)，therecommendedregimenisautologousperipheralstemcelltransplantation，if

8、resistancetochemotherapv’altlloughcanachieveremissionbutcannotreachCR1，suggestthatregimenisallogeneicperipheralstemcelltransplantation，iftheconventionalchemotherapvcannotreachremission，RICalloPBSCTwillbebatterKeyWords：PT