試劑ZS預(yù)防和治療大鼠亞硒酸鈉誘導(dǎo)的白內(nèi)障作用研究.pdf

1、分類號(hào)～——UBC密緞——學(xué)鴦!!望!!!碩士學(xué)位論文試劑ZS預(yù)防和治療大鼠避硒酸鈉誘導(dǎo)麓自內(nèi)障睪蔫研究尹沂指導(dǎo)教師陰成渤教授第互軍醫(yī)走學(xué)鷺南醫(yī)麓艱辯，400038臨床囂擘頸壬申請(qǐng)學(xué)位級(jí)別專業(yè)學(xué)位專業(yè)稻稱限科學(xué)論文提交糙麓2006年5舅論文答瓣鞠糍2006年5兵學(xué)位授予攀位和丑期第三軍醫(yī)大學(xué)2006年月鑄辮委員會(huì)主譬——二奎季黿0———————————～讒露天主；象：鏊餐一——二o0六年五月第三軍醫(yī)大學(xué)碩士學(xué)位論文Experimenta

2、lstudyonthepreventiveandtherapeuticaleffectsofagentZSonseleniteinducedcataractAbstractobjective：ToobservetheeffectofagentZSonseleniteinducedcataractouslensesofratsMethods：IPreventiveeffect：26Wistarratpups(day810postpartu

3、m)weredividedintothreegroups：normalcontrol、model、protectivegroupsThenormalgroupreceivedthenormalsaline(O1ml／109bW)byintraperitonealinjectiondailyfor6daysThemodelgroupreceivedsodiumselenite(301amol／kgbW、intraperitonealinj

4、ectiononlyonceTheprotectivegroupreceivedsodiumselenite(30Itmol／kgbW1intraperitonealinjectionfollowedbyagentZS(20pmol／kgbw)intraperitonealinjectionin30minutesinthefirstdayandthenreceivedagentZSdailyfor5consecutivedaysAtda

5、y7thetransparencyofalllenseswereobservedthroughslitlampmicroscopyAtthesametime，thelevelsofSuperoxidedismutase(SOD)、Malonaldehyde(MDA)weremeasuredrespectively2Therapeuticaleffect：55Wistarratpups(day810postpartum)receiveds

6、ubcutaneouslysodiumselenite(301amol／kgbW)Theratswithseleniteinducedcataractweredividedintotwogroups：gradeIVandgradeV，accordingtothedegreeofthelensopacityThenthetwogroupsweredividedrespectivelyintothreesubgroups：model、tre

7、atedfor1monthgroupandtreatedfor3monthsgroupsInthegradeIVgroup，themodelgroupwasadministereddailybyintraperitonealinjectionnormalsaline(O1ml／109bW)for3months；thetreatedfor1monthgroupwasadministereddailybyintraperitonealinj

8、ectionagentZS(20I_tmol／kgbW)for1month；thetreatedfor3monthgroupwasadministereddailybyintraperitonealinjectionagentZS(20／amol／kgb鉀1for3monthInthegradeVgroup，themodelgroupwasadministereddailybyintraperitonealinjectionnormal

9、saline(O1ml／109bW)for3monthsThetreatedfor1monthweredividedintothreegroups：eyedropapplication、lowdoseandhighdosegroupsTheeyedropapplicationgroupwasadministeredtwicedailybyeyedropapplication10mmol／LagentZSfor1months；thelow