血管內(nèi)皮生長因子和結(jié)腸癌的相關(guān)性研究.pdf

1、青島大學(xué)碩士學(xué)位論文血管內(nèi)皮生長因子和結(jié)腸癌的相關(guān)性研究姓名：李建國申請學(xué)位級別：碩士專業(yè)：人體解剖與組織胚胎學(xué)指導(dǎo)教師：王守彪20051119英文摘要THERESEARCHoNTUMoRANGIoGENESANDEXPRESSl0N0FVEGFINCOLoNICCANCERABSTRACTObjectiveToinvestigatetherelationshipbetweentumormicrovesseldensityandVEGF

2、、V口statusandtheColonictumorangiogensis、invasionandmetastasisSowecancomeintoinvestigatetherolesandclinicalsignificanceofVEGFandVmintheCOUlseofthecarcinogenesisMethodsUselightmicroscope，Verhoffhematoxylinandimmunohistoehem

3、istrytoviewthevascularendothelialcells，glandularcellsof10casesofnormalcolonictissue，90c國sesofcoloniccarcinomaResult1、VEGFalepositiveincoloniccarcinoma：Darkdyedgreatgrainscallbeobserved，arrangingabnormitly，thedensityaleFa

4、therthanthatinnormalcolonictissueTheexpressionofVEGFaredistributedinmarginoftheattackedtumorandthearoundofthenecrotissueOnlyfewsamplesCanbefullydyed2、TheexpressionofMVDincolonictumor：n磚micmvesselaredyedtopalmred，mainlydi

5、stributedaroundthemal#nofthecancerrange3、nleexpressionofVP：VIPareamblypositiveinthenormalcolonictissue。butalepositiveincolonicc戤in鋤扎4、11把relationshipofVEGF、Vm柚dthelransferofthetumoE11他expressionofVEGF、VPandmicrovesselden

6、sity(MVD)intransfergroupissignificantlyhiglIerthanthatinnontransfergroupTbeintensityofexpressionofVEGFhavepositivecorrelationwithmicrovesseldensityConclusionl、n忙histologyofcoloniccarcinomaisdifferentfromnormalcolonictiss

7、ue2、MicrovesseldensityandVEGFexpressionincolonictulnoragehighlycorrelatedwiththedepthoftumorinvasionandlymphnodemetastasis，whichmayserveasaparameterfordeterminingcolonicmetastasis3、V口immunologlcallycompetentendocrinecell

8、sc蛆resideandexpressincolonictissueSowecanuseVEGFandV口todeterminethebenignormalignantcoloniccarcinomaandmetastasishazard4、TheexpressionofVEGFandVIPchangefromlowtohighintheprocessfromnormalcoloniCtissuetocoloniccarcinomaKe