主流煙氣中芳香胺的提取、衍生條件的優(yōu)化及市售卷煙芳香胺含量的GC-MS測定研究.pdf

1、貴州大學(xué)碩士學(xué)位論文主流煙氣中芳香胺的提取、衍生條件的優(yōu)化及市售卷煙芳香胺含量的GCMS測定研究姓名：謝建玲申請學(xué)位級別：碩士專業(yè)：化學(xué)工藝指導(dǎo)教師：楊敏彭黔榮200806012008貴州人學(xué)碩I：學(xué)位論文ABSTRACTTobaccoindustryhasbeensupportedourgovernmentfinanceincomeTheindustryfocusesonthedevelopmentoflowharmfulcigare

2、tteAromaticamineshavebeenclassifiedascarcinogens，foundintobaccosmoke，inparticularly1naphthylamine，2一naphthylamine，3一Aminobipheny，and4AminobiphenyTherefore，itishi曲lydesirabletoestablishasimpleandefficientmethodforthetrace

3、determinationofaromaticaminesintobaccosmoke，toassessthesafetyoftobaccobytheamountreleasedofaromaticaminefromtobaccosmokeItisreportedthataromaticaminesintobaccosmokewerederivatizedaspentafluoropropionamidesandmeasuredbyga

4、schromatography／massspectrometryintheselectedion—monitoringmode，whichwasasensitiveandaccuratemethodReexaminingtheprocedure，wefoundthatitisnoteasytogetgooddeterminationofaromaticaminesintobaccosmoke，duetoinvolvingmanyproc

5、ess，suchasextration，derivatization，purificationandcontrolofGC—MSTherefore，weinvestigatedtheinfluenceofdiverseparametersontheextractionandthederivatizationprocessofaromaticaminesintobaccosmoke，includingtheextractionmode，e

6、xtractiontime，extractiontemperature，concentrationofHClsolution，concentrationofsodiumhydroxidesolution，pHvalue，derivativereagentkind，derivativetemperature，derivativetime，amountofderivativereagentandelutionsolutionUnderthe

7、optimizedconditions，aromaticaminescouldbeseparatedanddetectedwithin15minThedetectionlimitsof3aminobiphenyl，4aminobiphenyl，1naphthylamine，2naphthylamineareO13，O10，O12，O09ng／LTherecoveriesofaromaticaminesrangedfrom9372％to1

8、0422％Therelativestandardderivationsrangedfrom321％to47％ThismethodwasappliedtothedeterminationoftracearomaticaminesinmainstreamsmokewithgoodresultInaddition，nucleariodinationhasbeenexaminedpreliminaryinthisworkasanalternat

9、ivederivatizationreactionIodinationisarelativelymoderateprocess，albeit，itisnotsubjectedtosidereactionsandnotrestrictedtoanhydrOUSmediaAfterfurtherinvestigationofcorrelationcoefficient，limitofdetection，relativestandarddev

10、iations，andtherecoveriesofaromaticaminesbytheuseofthenucleariodination，andapromisingmethodwillbeestablished，whichissampleandefficientoneforthetracedeterminationofaromaticaminesintobaccosmokeKeyWord：Gaschromatographyselec