亞銨陽離子型脫水劑制備與應(yīng)用及超聲波輻射下肟的還原.pdf

1、河北大學(xué)碩士學(xué)位論文亞銨陽離子型脫水劑制備與應(yīng)用及超聲波輻射下肟的還原姓名：劉蕊艷申請學(xué)位級別：碩士專業(yè)：藥物化學(xué)指導(dǎo)教師：曹玉慶20100601Abstract IIAbstract Primary study on the synthesis of a new Immonium Type dehydrating agent and the preliminary Application in the conversion of al

2、doximes into nitriles were reported. Besides, a variety of amines were synthesized under ultrasonic irradiation with zinc and acetic acid in satisfactory yields. This thesis consists of three chapters. Chapter 1: Preface

3、 Chapter 2: Synthesis of a new Immonium type dehydrating agent NHPI-DMF due to the advantages of readily available reagents and ease of work-up. Aldoximes were converted into corresponding nitriles by using NHPI-DMF as d

4、ehydrating agent. The results showed that the method has features of mild reaction conditions,ease of work-up and high yields. Chapter 3: A variety of oximes were reduced into corresponding amines with zinc and acetic ac

5、id under Ultrasonic Irradiation. The high yields and ease of work-up together with eco-friendly conditions should make this protocol an important addition to the currently available methods. Keywords Immonium Type Dehyd