長白山白樺樹皮中白樺脂醇的提取、衍生化及生物活性研究.pdf

1、東北師范大學(xué)碩士學(xué)位論文長白山白樺樹皮中白樺脂醇的提取、衍生化及生物活性研究姓名：祁逸梅申請學(xué)位級別：碩士專業(yè)：有機化學(xué)指導(dǎo)教師：李建新20050501AbstractBetulinandbetulinicacidareremarkablenaatralproductsTheyareobtainedfromavarietyofbotanicalsourcesandbetnlinicacidcanbeeasilypreparedfromt

2、hemoreplentifulprecursorbetulininasimpletwo—stepprocessBetulin，betulinicacidandmanyoftheirderivativesexhibitgreatpromiseasbioactiveagentsforthetreaUnentofHIVinfectionandcancerItissignificanttostudythepharmaceuticalactivi

3、tiesofbetulin，betulinicacidandtheirderivativesandtoconfirmtherelationshipbetweentheirconstructionandactivityforselectingthemoreeMcientmedicineInourcountry，birchsourcesareenriched，buttheERIehavebeenexpl01】ed。Inconsequence

4、，wedecidetostudythesourcesofChangbaiMountainbirchThemaincontentofthisthesisasfollowing：1，ThecontainofbetulinandbetulinicacidareanalyzedbyGC。Thecontainofbetulinis1825％andbetulinicacidisO975％Thereforeitisremarkablypromisin

5、gtoexploretheChangbaiMountainbirchSOUrCes，2Wehaveextractedbetulin(comp1)fromChangbaiMountainbirchbark，Inmeantime，wedesignandsythesize4compoundsand1intermediateTheyarecharacterizedby。HNMR，”CNMRandIR3Inordertoinvestigateth

6、eirbiologicalactivities，4medicalregentsaretestedinvitroagainstoesophaguscancercellsECl09usingMTrassayItisindicatedthatthesecompoundsexhibitsatisfactoryactivities，Especially，betnlinicacidandextractedcompoundexhibitmoreexc