幾個天然香豆素的合成研究.pdf

1、西北農(nóng)林科技大學碩士學位論文幾個天然香豆素的合成研究姓名：王進申請學位級別：碩士專業(yè)：應用化學指導教師：周樂20080601STUDYONTHESYNTHESISOFSEVERALNATURALCOUMARINSABSTRACTN刪coumaIiIlshaVem鋤【ykiIldsofbioac廿Vitiesandt0XicitiesIn吐lisp印er，t11esyllmesisofmLnlralcouln矗riIlswercre嬲er

2、chl覓andeightsimple城m】ralco呦a面【lsweres”油esizedExp甜lncntsofmeirsele“VeⅫling—fishactiVit)，默淝conductedSi)【coullla曲lsweresynthesizedViaWittigreactionusing‘‘0nepot，’metllod皿1eprocedluesare嬲fowllowEqu甜鋤ountoftripheIlylphoSplliI

3、leaIldcldoroethylacetate、Ⅳe糟IIlixediIlt0tllesolVentofdryethanol，thewhole111i)(1urewereheatedtiUreactionisoVerEqual鋤ountofpurcsodiumw嬲缸IdedAfterthereaCtio瑪addhalf鋤ountofsalicylaldehyde，也ewholesystemwausheatedto80℃foroneho

4、uLThes01ventwasev印orated，廿lecrudemi)mlrewasex饑lCteduSiI堰ethylacetatea11dsI蛔ectedtocolu瑚nchromat0鯽hyt0酉VepureproductsmirrrLCpu哪che出ng，meltingpo硫，R，MSa11d1H№很show恤teachofmemareA(眥1beUiferone)，B3(5，7dmydroxyco啪arin)，C2(scop

5、olet喲，Dl(daplllle血1)，E(8一me缸loxyc01un撕n)，F(xiàn)2(6hyd∞xyc0唧arin)T、Ⅳ0omercoumari璐、VeresynmesizedviaPechm鋤reac廿on，theprocedu嶺are弱followHydroXyquin01triacetatew嬲pr印aredfrompbenzoqllinOneby1，4additionrcaction、)l，itllaCeticanhydri

6、deandtllenG(escllletin)w嬲s)，ntllesized五舊mitbyhydrolyzitionandcyclizationiIlconcemratedsul如ricacidH(Scoparone)、瑚s“岫esizedbymethylating丘omesculetinRelatedp面鑼chec她肌d1H№僅co碰nnedmeirchemic2LlcoImgul謝onSEXperimentsofl【iUingfis

7、hshowthat觚longtheeightco啪arins，C2，Ea11dF2havetoxicitiestow雒dfishE【perimentsofthctllreecoumariIls’activitiestowardfishanddap嘶ashowmatEaIldF2腳epotentialuSeofselectiVepondcle撕ngAtl勰t，wefoulldⅡle鉚ocoumarinS’mgesofselectivepo

8、nd—cleaniI瑪conCen_tratioIl，theupperl抽1itofE’sconcen臼ationisabout75～l0ppm，nlelo、Verlimitis1ppm；whileF2’supper1imitisabout20~30ppm，itslowerlilllitislppm髓YWORDS：Mmgreaction，Pech鋤reaction，actiV蚵ofkillingfish，selectivepondcle