內(nèi)質(zhì)網(wǎng)蛋白穩(wěn)態(tài)在不同來源腫瘤及乳腺癌干細胞的調(diào)控中的作用機制研究.pdf

1、北京協(xié)和醫(yī)學院博士研究生學位論文博士學位論文學校代碼：10023學號：B2012005002內(nèi)質(zhì)網(wǎng)蛋白穩(wěn)態(tài)在不同來源腫瘤及乳腺癌干細胞的調(diào)控中的作用機制研究所院：姓名：指導教師：導師小組：學科專業(yè)：研究方向：完成日期：中國醫(yī)學科學院基礎(chǔ)醫(yī)學研究所李闖王林教授王林教授生理學內(nèi)質(zhì)網(wǎng)應(yīng)激與腫瘤發(fā)生2016年4月北京協(xié)和醫(yī)學院博士研究生學位論文B2012005002AEBSFATF4ATF6B滬C／EBP6CHIPCHOPeIF2EMTERER

2、ADGAPDHGI沖78HRDlII也llIFllNFKB0ct4PARPPDIPERKIUDDS102Sox2UPRVCPXBP1縮略語4(2一Aminoethyl)benzenesulfonylfluorideactivatingtranscriptionfactor4activatingtranscriptionfactor6immunoglobulinheavychainbindingproteinCCAAT—enhancer—

3、bindingprotein6CterminusofHSC70InteractingProteinC／EBPhomologousproteineukaryotictranslationintiationfactor一2epithelial—mesenchymaltransitionendoplasmicreticulumendoplasmicreticulumassociateddegradationglyceraldehyde3pho

4、sphatedehydrogenaseglucose—regulatedprotein78HydroxymethylglutarylcoenzymeAreductasedegradationprotein1inositolrequiringenzyme1kinesinfamilymember11nuclearfactorrd3octamerbindingtranscriptionfactor4PolyADPribosepolymeras

5、eProteindisulfideisomeraseProteinKinaseRlikeERkinaseregulatedIre1dependentdecaySphasekinase2sexdeterminingregionYbox2unfoldedproteinresponsevalosincontainingproteinXboxbindingprotein—l3苯磺酰氟鹽酸鹽激活轉(zhuǎn)錄因子4激活轉(zhuǎn)錄因子6免疫球蛋白結(jié)合蛋白CCAAT