氟代苯甲醛的合成研究.pdf

1、南京理工大學(xué)碩士學(xué)位論文氟代苯甲醛的合成研究姓名：秦海芳申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：蔡春方永勤20080515Abstract碩：論文AbstractFluorobenzaldehydeisanintermediateforpreparingmedicine，pesticide，spice，dyestuffandotherfinechemicalsInthesynthesisofmedicineandpesticide，t

2、heintroductionoftheatomFCanimprovebiologicalactivityanddrugeffectandreducetheadverseeffectCurrently，theapplicationoffluorobenzaldehydehasbeencontinuouslyextendedInthispapertwomethodsforthesynthesisofP—fluorobenzaldehydef

3、romPfluorotoluenehavebeenstudiedThesynthesisofp—fluorobenzaldehydebychlorinationandhydrolysisWillsstudiedTheinfuenceofsolvent，catalystandotherreactionconditionsonexperimentresultwerediscussedThereactionconditioninthehydr

4、olysisofmixedchlorideproductsviahexamethylenetetraminewasn(4fluorobenzylchloride)：n(hexamethylenetetramine)=l：4，m(chloride)：m(ethan01)=1：11theyieldWas801％Theyieldwas952％inthehydrolysisofP—fluorodichloromethylbenzeneineth

5、anolwiththereactionconditionofV(p—fluorodichloromethylbenzene)：V(ethan01)21：5ThereactionconditioninthehydrolysisfollowedwithoxidationfromP—fluorobenzylchloridewas：n(4fluorobefizalcoh01)：n(hydrogenperoxide)2l：13，n(sodiumt

6、ungstate)：n(salicylicacid)=l：1theyieldWas784％Thesynthesisofpfluorobenzaldehydebygas—liquidtwophaseoxidationWiltsstudiedTheinfluenceofsolvent，catalyst，oxidant，temperatureandotherreactionconditionsonexperimentresultweredis

7、cussedUndertheoptimumconditionofV(p—fluorotoluene)：V(glacialaceticacid)=l：3，n(cobaltousacetate)：n(manganeseacetate)：n(potassiumbromide)=l：23，reactiontemperature9095“(2，oxygenflow24mL／min，theconversionofpfluorotolueneWas2