海洋真菌ZZF27和SCP05以及放線菌195-02的代謝產(chǎn)物研究.pdf

1、中山大學(xué)碩士學(xué)位論文海洋真菌ZZF27和SCP05以及放線菌19502的代謝產(chǎn)物研究專業(yè)：有機化學(xué)姓名：胡智勇導(dǎo)師：林永成教授各辯孌員會孌員(簽名)主席：哮俐幼委員吻一，、彰毒粗袱辦1氟二00五年六月中山大學(xué)碩士學(xué)位論文AbstractAstheresearchofmarinebioactivesubstancesstrengthensconstantly，marinemicroorganismgetstheworldtofocusat

2、tentionRecentlymarinemicroorganismshaveprovedtoproduceavarietyofchemicallyinterestingandbiologicallysignificantsecondarymetabolitesWiththedeveiopmentofgeneticengineering，theresearchonmetabolitesofmarinemicroorganismwillm

3、akegreaterprogressInthispaperwehaveculturedthreemarinemicroorganismsusingmodernbiologicaltechnologyandhavestudiedthemetabofitesofthemforthefirsttimeByfarwehavegottwentyonecompoundsaltogetherPartialcompoundshaveproventoha

4、vebioactivityandoneofthemisfirstisolatedfrommarinemicroorganismsFromthemarinefungiZZF27，sevencompoundswereobtainedTheyareterephthalicaciddimethylester6acetyl4methoxy一3methylpyran一2一one2butyl一3一methylsuccinieacid，allantoi

5、n，5methyluracilergosterol，pero—ergoster01StudiesonthemetabolitesofmarinefungiSCP05ledtoisohtionofninecompounds，including：5一butylpyridine2一carboxylicacid，tetradecanoicacid，cyclo(Gly。Phe)，cyclo(PheTyr)，isocoumarinacid，7，22

6、diene3，5，6trihedroxyergosterol，succinicacid，uracilandmannit01OninvestigationofthemarineActinomyeete195—02，fivecompoundswereobtainedTheyarephydroxyhenzonitrile，2methylfuran3一carboxylicacid，F(xiàn)uran一2。carboxylicacid，cyclo(Phe