測定血清CA72-4、CA19-9、CEA水平在胃癌診治中的價值和應(yīng)用.pdf

1、福建醫(yī)科大學(xué)碩士學(xué)位論文測定血清CA724、CA199、CEA水平在胃癌診治中的價值和應(yīng)用姓名：張宇申請學(xué)位級別：碩士專業(yè)：外科學(xué)（普外）指導(dǎo)教師：李良慶20090301TheapplicationandvalueofmeasuringserumCA72—4，CAl9—9，CEAstandardincureofgastriccarcinomaAbstractObjective：ToevaluatethevalueofserumCA724

2、，CAl99，CEAstandardingastricCanCerdiagnosisthroughROCculwesanddiseriminantanalysisAnd，alsotodiscovertheapplicationofserumtumormarkers(TM)aswellasitsapplicationincureofgaSlriccancerandpredictingprognosisthroughthewayofanal

3、yzingtheimpactfactorsonTMstandardMethod：MeasuretheSewLImCA724，CAl99，CEAstandardof85caSesingaStriccancel“groupand146casesincontrolgroup，thenevaluatethecaseofusing3kindsofTMseparatelyandthecaseofusingthemtogetherthroughROC

4、curvesanddiscriminantanalysisAnddiscoverhowtouse3kindsofTMserumstandardtodiagnosegaStriccancerWiththehelpofrelationstothepathologyofgastriccancerpatients，analyzetheimpactfactorsof3serumTMstandardanddiscovertheirapplicati

5、onsinfuturecureofgastriccancel“andpredictingprognosisStatistics：UseSPSS170andMedCalcsoRwarepackagetoanalyzethedataTheadoptedstatisticsalgorithmsareROCcurves，nonparametricranksumtest，discriminantanalysisandcorrelationanal

6、ysisResult：ThemeanlevelofserumCA72—4，CAl9—9andCEAingastriccancel“groupishigherthantheonesincontrolgroupComparingusingonlyCA72—4todiagnosegastriccancertousingCA724，CA19—9andCEAtogethertodiagnosegastriccancertheirAUCvaluei

7、sO768andO710separatelytherearenostaffsticaldifferencebetweenthetwomethods’AUCvalueBothofthetwomethodsarebetterthanusingonlyCA199orCEAByusingtheROCcurve，thecutoffvaluesetto165U／mlwhenusingonlyCA724todiagnosegastricCanCerm

8、akestheYoudenindexvaluebiggerandinthiscaseindexesare：Se：6118％，Sp：7808％，Y；oudenindex：0393Thetypicaldiseriminantformulaofusing3kindsofTMtogethertodiagnosegastriccanceris：D=0015Xl0011X20081X30597(X1，X2andX3isthemeasuremento