多羥基甾醇25（R）-螺甾環(huán)-5-烯-2β，3a，19-三醇的合成.pdf

1、鄭州大學(xué)碩士學(xué)位論文多羥基甾醇25（R）螺甾環(huán)5烯2β，3a，19三醇的合成姓名：金志敏申請學(xué)位級別：碩士專業(yè)：材料學(xué)指導(dǎo)教師：王紅英張靜夏20070501AbstractAbstractThesterolsexhibitedpotentialbioactivitiessuchasantitumorcytotoxicantibacterial，antifoulingantiflammationandanticardiovasculard

2、iseaseactivityItisaclassofpromisingprospectsforthedevelopmentofnewdrugcompoundsLaterpeoplefoundsterolsalso#ayaveryimportantroleinthenervoussystemThediscoveryofneurosteroidsopensupanewfieldinthebrainandshowsmoreandmoreimp

3、ortantbecauseofmanyevidencesindicatesthatneuroactivesteroidsplayanimportantroleinbrainfunction，especiallyinthehigherbrainfunctionsuchaslearningandmemorycognitive，emotionalInthispaperthemaincontentsandtheresultsaleasfollo

4、ws：(1)Wehavethebasisofthestructureactivit)rrelationshipoftheneuroprotectivesterols，SOwedecidedtosynthesisthepolyhydroxyster6125(R)一spirost5一cIl一2B，3a，19一triolwithaviewtotheapplicationofneuralprotection(2)Wedesignedtherou

5、teofsynthesisingthepolyhydroxysterol25(R)一spirost5一en2p，3a19tri01ItWassynthesizedfromcheapdiosgeninbySevenstepswhichcontainedsulfurylreaction，oxidativeadditionreactionwithNBS，farwayoxidationofPb(OAc)4，elimination，oxiddif

6、ionofmCPBAandreductionwithZnpowder(3)Wedescribedthestepsofsynthesising25(R)一spirost5一en213，3ct，19一trioldetailedlyTheirstructureswereelucidatedbyIR、IHNMR、BCNMR、MSandEAMainlythrough1HNMR、13CNMR、MSanalysisconfirmedthedetail

7、sofvariousintermediatesand25(R)spirost一5an2p，3a，19一tri01NOESYconfirmedthatthestuctureoftargetproduotis2D，3aconfiguration(4)Weconfirmedthatanotherpolyhydroxysterolis25(R)一spirost5aH一2B，3a，19tri01(5)Wegettheconclusionthatt

8、herewereonly2，3epoxypenringand6，19oxygenbridgestructureWasnotchangedintheconditionsexistingperchlorateThespirostringshavenotchangedinthisSeVenstepreactionconditionsKeywords：Diosgenin；Polyhydroxysterol；25(R)一spirost5一en21