黃酮-8-羧酸類化合物的合成與表征.pdf

1、南昌大學(xué)碩士學(xué)位論文黃酮8羧酸類化合物的合成與表征姓名：陳丹丹申請學(xué)位級別：碩士專業(yè)：有機化學(xué)指導(dǎo)教師：溫輝梁劉崇波20081217AbstractAbstractFlavonoidsarecompoundsfullofbiologicalactivitiesandspecialplasticstructure，andthetoxicityisextremelysmallwhichattractmanyscientistsformore

2、thanonehundredyearsTosynthesizefalconoidandmodifystructureisahottopicofmanyorganicchemistsandpharmacyjuristsTllecarboxylisintroducedtomatrixoffalconoidwhichCanincreasetheactiveiSahotresearchtopicinthisfieldInthisthesis，w

3、ehaveselectedtheflavonecarboxylicacidsasthetarget，synthesized，characterizedaseriesofflavone8carboxylicacidandoptimizedthereactionconditionsThispaperwascardedoutasfollows：Firstlytherecentprogressofthebiologicalactivities，

4、synthesis，andstructure—activityrelationshipoftheflavonecarboxylicacidshasbeenreviewedextensivelybasedonthedetailedinvestigationofrelatedliteraturesSecondly，itWasstudiedabouttheeffectsonsynthesisreactionofdifferentsolvent

5、s，ratioofreactants，thedosageandconcentrationofalkaliandfourchalconescompoundsweresynthesized，threeofthemwerenewcompoundswhichhaven’tbeenreportedTheirreactionconditionswereoptimizedtooThissyntheticrouteprovidedadirectionf

6、ortheresearchofsynthesizingchalconeinagreen，environmentalprotectionmethodThirdlythesynthesisofflavonecarboxylicacidsinconditionsofmicrowaveradiationand12／DMSOastheoxidantWasstudied，eightflavone一8一carboxylicacidcompoundsw

7、eresynthesizedandtheirreactionconditionswereoptimizedTheirstructureswerecharacterizedbyIRHNMRandMS(ESI)Sevenofthemwerenewcompoundswhichhaven’tbeenreportedAdvantagesofthismethodareshortreactiontime，simplereactionprocessan

8、dhighyieldFourthly，onecrystalsoftheflavone8一carboxylicacidderivativeswereobtainedandtheircrystalstructuresweredetectedbythesinglecrystalXraydiffractionTheircrystalstructureWaSstudiedforthefirsttimewhichprovidedtheoretica