地塞米松和左旋咪唑?qū)﹄u體液免疫反應(yīng)的影響.pdf

1、華中農(nóng)業(yè)大學(xué)碩士學(xué)位論文地塞米松和左旋咪唑?qū)﹄u體液免疫反應(yīng)的影響姓名：竇樹龍申請學(xué)位級別：碩士專業(yè)：基礎(chǔ)獸醫(yī)學(xué)指導(dǎo)教師：操繼躍2002.5.1TheEffectsofDexamethasoneandLevamisoleonHumoralImmuneResponseinChicksVeterinarypharmacologyGraduate：DoushulongAdvisor：CaojiyueAbstract：Dexamethasone(

2、Dex)andlevamisote(Lev)areusedonveterinayclinicfrequently，whichpossiblyinfluencethehumoralimmunityresponseofanimalsChickswereadministeredDexandLevatdifferentdosagesbydrinkingfor5daysduringthefirstinoculatingperiodandwereb

3、oosteredatpropertimeforinvestigatingtheeffectsofthedrugsonantibodyproductionBloodsampleswerecollectedat19，26，34，42，49，56daysTheNewcastledisease(ND)andtheinfectiousbursaldisease(IBD)antibodytitersweredeterminedbyhemagglut

4、inationinhibition(HI)andindirecthemagglutinationtestrespectivelyThecollecteddatawereanalyzedbyttestTheresultsindicatedthatnosignificantlylowerresponsewasmeasuredinchicksthatreceivedDexatalowdosageof05mg／L(P005)，whereasan

5、tibodytitersweresignificantlydecreasedinchicksthatreceivedthedrugeitheratamiddledosageof25mg／Loratahighdosageof75m∥L(P005)ThehumoralimmuneresponseimpairmentcausedbyDexcouldbecontroledandtheantibodytiterscouldbeadjustedto

6、controllevelorevenhigherthancontrol(P005)byusingLevatlowormiddledose，buttheimmunosuppressioninducedbyDexcouldn’tbereversedbyusingLevathighdosageof125mg／LrP005)ItcanbeconcludedthatLevisagoodimmunoaccelerantandDexshouldbeu

7、sedatproperdosagebecauseofthehumoralimmuneresponseimpairmentcausedbyitatmiddleorhighdoseThephenomenathattheimpairmentcausedbyDexcanbereversedbyLevatproperdosagelayastablefoundationforthedevelopingofnewmedicamentwithadvan