29342.芳并多元含氮雜環(huán)骨架的構(gòu)建

1、獨(dú)創(chuàng)性聲明本人聲明所呈交的論文是我個人在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果。盡我所知，除了文中特別加以標(biāo)注和致謝的地方外，論文中不包含其他人已經(jīng)發(fā)表或撰寫過的研究成果，也不包含為獲得寧夏大學(xué)或其它教育機(jī)構(gòu)的學(xué)位或證書而使用過的材料。與我一同工作的同志對本研究所做的任何貢獻(xiàn)均已在論文中作了明確的說明并表示了謝意。研究生簽名‘哆晚葡時(shí)間：馴轤年f月矽曰關(guān)于論文使用授權(quán)的說明本人完全了解寧夏大學(xué)有關(guān)保留、使用學(xué)位論文的規(guī)定，即：學(xué)校有權(quán)

2、保留送交論文的復(fù)印件和磁盤，允許論文被查閱和借閱，可以采用影印、縮印或掃描等復(fù)制手段保存、匯編學(xué)位論文。同意寧夏大學(xué)可以用不同方式在不同媒體上發(fā)表、傳播學(xué)位論文的全部或部分內(nèi)容。(保密的學(xué)位論文在解密后應(yīng)遵守此協(xié)議)躲哆玩御翩攤：咨，●—‘一’lI／時(shí)間：汐／矽年g月彩相時(shí)間：刀蚱j月糾日AbstractThethesisfocusesontheconstructionofthefusedazapolycyclicskeletonthr

3、oughtheintramolecularSchmidtreactionofacylchlorideswithalkylazidesThekeyinnovationoftheresearchistocontrolthemigrationgroupoftheSchmidtreactionofacylchlorides，andtheNacyliminiumionsisaddressedthrough12一migrationofamethin

4、egroupoverthemethylenegroupwiththedesigned(oazidocarboxylicacidsTheintramolecularcaptureoftheNacyliminiumionswitharomaticringsisdocumented，whichavoidsthe10SSofcarbonatomandenhRacestheatomefficiencyoftherelatedconversionT

5、hedissertationiscomposedbythefollowingthreeparts：mmefnstparttheclassicSchmidtreactionofcarboxylicacidswithhydrazoicacidhasbeenreviewedGenerally，theproductsareone—carbonshorterhomologsofthesubstratesThepossiblemechanisman

6、dtheprocessoftheconversionareintroducedhereIIlmesecondparttheSchmidtreactionofacylchloridesispresentedTheSchmidtreactionofacylchlorideswithalkylazidesthroughNacyliminiumionintermediateshasbeendesignedandrealizedSeveral(o

7、azidocarboxylicacidshavebeenconvertedtothecorrespondingbenzofusedlactamsthroughtheonepotprotocolcombiningacylchlorination，Schmidtreaction，andPictetSpenglercyclizationTheimportantfeatureofthedominoprocessistheefficiencyin

8、bondreorganization(threenewbondsincludingoneCCandtwoCNbondsformed，meanwhileoneCCbondbroken)andringformation(bicyclicskeletonconstructed)Inthelastparttheexperimentaldetailsoftheconversionandspec仃oscopydataareprovided，whic

9、hincludesthepreparationofalltheintermediates，the∞azidocarboxylicacids，andtheonepotconversioncombiningwithacylchlorination，Schmidtreaction，andPictetSpenglercyclizationKeyWords：SchmidtReaction，NacyliminiumIons，PictetSpengl