27071.微管的力學(xué)性能：連續(xù)體描述與分子模擬

1、蘭州大學(xué)碩士學(xué)位論文微管的力學(xué)性能：連續(xù)體描述與分子模擬姓名：雷芳明申請學(xué)位級別：碩士專業(yè)：力學(xué)、固體力學(xué)指導(dǎo)教師：高原文20100601蘭州大學(xué)碩士學(xué)位論文AbstractAsthebasicelementoflife，therehavebeenalotofstudiesonthemechanicalbehaviorsofcellThecytoskeleton(CSK)isaselforganizingfilamentsnetwork

2、inalleukaryotes，TheCSKisadynamic，livingstructurethatdefinesthecell’Sshapeandbulkmechanicalproperties，Manycellularfunctionssuchascelldivision，motility，signaltransduction，etcaremediatedbythephysicalpropertiesofCSKTheCSKnet

3、workconsistsofthreeprimaryproteinfilaments：microtubules(MTs)，intermediatefilements，andactinfilementsAmongthethreetypesofCSKfilaments，microtubulesarethemostrigidSOthemicrotubulesplayanessentialrolesinthemechanicalproperti

4、esofcellThisthesisisfocusingoninvestigatingthemechanicalbehaviorsofMTsThespecificworksfinishedarelistedbelow：●AnonlocalTimoshenkobeammodelwithconsiderationofthewormlikechainmodel(WLC)hasbeendevelopedfortheMTSAnewpersiste

5、ncelengthpredictionformulawithconsiderationofthesmallscaleeffecthasbeenpresentedThepredicatedresultsofourmodelindicatethatthepersistencelengthincreaseswhilethecontourlengthoftheMTisincreasing，andthepersistencelengthtends

6、toaconstantvaluewhilethecontourlengthislargeenoughTheEulerbeammodelshowsthepersistencelengthisaconstantvalue，whichisalwaysconsideredunabletoexplainthelength—dependenceofmicrotubules●BaseonthenonlocalTimoshenkobeammodel，t

7、hebucklingbehavioroftheMTsurroundedbythecytosolunderaxialcompressionhasbeeninvestigatedTheintermediatefilamentsareassumedasanelasticmedium，TheanalyticalexpressionofthebucklinggrowthratehasbeenpresentedTheresultsshowthatt