14347.新型的天冬氨酰蛋白酶抑制劑yf0200ra和b的合成和研究

1、分類號(hào)UDC密級(jí)公開暑哦諍產(chǎn)篝碩士研究生學(xué)位論文新型的天冬氨酰蛋白酶抑制劑YF0200RA和B的合成和研究申請(qǐng)人：王曉丹學(xué)號(hào)：2131132培養(yǎng)單位：化學(xué)化工與材料學(xué)院學(xué)科專業(yè)：有機(jī)化學(xué)研究方向：藥物合成化學(xué)指導(dǎo)教師：侯艷君教授伍貽康研究員完成日期：2016年3月18日黑龍江大學(xué)碩士學(xué)位論文AbstractThisthesisintroducedthetotalsynthesisoftwonaturalunsaturatedfattya

2、cidswithaspargylproteaseinhibitionactivityTherelativeconfigurationandtheabsoluteconfigurationwereconfirmedBothofthesenaturalcompoundswerefirstlyseparatedfromsouthernSumatrasoilsamplesTheplanarstructureswerestudiedbynucle

3、armagneticresonance(NMR)，massspectrometryandotherinstrumentanalysismethods，buttherelativeconfigurationandabsoluteconfigurationwerenotdeterminedInthispapertwopartswerewrittentointroducetheprocessesoftotalpreparationoffour

4、compoundsTheprocessofpreparing(2E，4E，8R，10R)and(2E，4E，8S，1OR)一8，10，12一trihydroxydodeca2，4dienoicacidwasintroducedinthefirstpartDglucosewasusedasrarematerialtOinstallepoxychiralbuildingblocksThefinalproductionwassynthesiz

5、edbyradicalmediateddeoxygenation，Homer—Wadsworth—EmmonsreactionandotherreactionsTheabsoluteconfigurationsfornaturalYF一0200RBcouldbereliablyassignedas(ss，10S)byanalyzingthespectroscopicdata，IHNMRand13CNMRInthesecondpart，(

6、8R，2E，4E)and(8S，2E，4E)一8，12一dihydroxydodeca一2，4dienoicacidweretotallysynthesizedDuringtheprocess，asymmetricailylation，hydroboration，oxidationandHomerWadsworthEmmonsreactionwereusedtopreparetheopticallyactivetargetcompoun

7、dswith(8R)and(8S)configurations，respectivelyAssignmentsoftheabsoluteconfigurations，(8s)，ofYF一0200RAweremadeonthebasisofcomparisonofthe1Hand13CNMRaswellasopticalrotationsKeywords：naturalproducts，totalsynthesis，chiralpool，