14358.過渡金屬催化芳烴ch鍵的氰基化反應(yīng)

1、分類號UDC密級筮五多毋廬夕擎碩士研究生學(xué)位論文過渡金屬催化芳烴C—H鍵的氰基化反應(yīng)申請人：學(xué)號：培養(yǎng)單位：學(xué)科專業(yè)：研究方向：指導(dǎo)教師：完成日期：王璐璐2131345化學(xué)化工與材料學(xué)院應(yīng)用化學(xué)精細有機化學(xué)與技術(shù)孫志忠教授初文毅副教授2016年3月20日黑龍江大學(xué)碩士學(xué)位論文AbstractArylnitrilesaskeystructuralunitsexistinnumerousdyes，pesticides，pharmaceuti

2、calsandnaturalproductsTherefore，thepreparationofnitrileshasalwaysbeenanattractivetopicinorganicsynthesisInthepastdecades，transitionmetalcatalyzeddirectCHcyanationwasstillanappealingstrategytosynthesizearomaticnitrilesIta

3、voidsthedisadvantagesofgeneralmethodssuchasharshreactionconditionsandtheuseofstoichiometricamountsoftoxicmetalcyanidesThispaperdevelopedabidentatechelationassistantpalladiumcatalyzeddirectCHcyanationofpicolinamideswithTM

4、SCNAmidewaschoosenasthedirectinggrouptosynthesizemonodentateN一(naphthalen1一y1)benzamide，2chloro—N一(naphthalen一1一y1)nicotinamide，N一(quino—lin一8一y1)benzamideandNO—bidentatechelatedN一(naphthalen一1一y1)furan一2carboxamide，N，N—

5、bidentatechelatedN一(naphthalen一1一y1)picolinamideAftercomparisonoftheirreactivitywechoseN(naphthalen1y1)picolinamideassubstratesand17derivativeshavebeensynthesizedThereactionofN一(naphthalen一1一y1)picolinamideinthepresenceo

6、fPd(PPh3)4ascatalystandTMSCNascyanidesourcewasinvestigatedInordertoimprovetheyield，thereactionwasconductedbychangingthereactionparameters，includingcatalyst，oxidant，cyanatingreagent，solvent，temperatureandatmosphereHavinge

7、stablishedtheoptimizedreactionconditions，thegeneralityofthereactionwasinvestigatedbyusingvarioussubstratesAtlast，14aromaticnitrileshavebeenachievedMoreoveramechanismofthiscyanationreactionwasproposedKeywords：Arylnitriles