聚乳酸載柔紅霉素和姜黃素納米微球的制備及其釋藥性能研究

1、武漢理工大學(xué)碩士學(xué)位論文聚乳酸載柔紅霉素和姜黃素納米微球的制備及其釋藥性能研究姓名：曹瑞銳申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：張勝民20050501AbstractPolymernanoparticlesrefertoparticles，whichsizearrangesfrom10～1000nmandpreparedthroughnaturalorsyntheticpolymers，includingnanospheresand

2、nanocapsulesNanoparticleshavebecomeanimportantareaofresearchinthefieldofdrugdeliveryrecentlyandhavereceivedmuchattentionbecausetheirabilitytodeliverawiderangeofdrugstovaryingareasofthebodyforsustainedperiodsoftimethrough

3、dissolveembolismencapsulationoradsorptionthemodeldmgintopolymericmatrixInthisthesis，wefabricatethePDLLAnanospherescontainingDaunorubicin(DNR)andCurcumintoapproachtheeffficientmethodtopreparedrugcontainedPDLLAnanospheress

4、ystemAboutthesetwomodeldrugDNRiswatersolubleItsefficacyisrestrictedbyshorthalflifeandeasilytodecomposed，alsobyitsseveralcardiotoxicityandmyelosuppressionCurcuminispharmacologicalsafetybutwithalowbioavailabilitywhichismuc

5、hduetoitswaterinsolublepropertyThesedefectshaveseverallimitedtheapplicationprospectofDNRandCurcumininclincTheencapsulationofthesedrugswithPDLLAnanospheresisexpectedtoimprovethetargetefficiencyofcytostaticagentinchemother

6、apyandreducedragassociatedsideeffects，aswellastheimprovementthehydrophilicityofwaterinsolubledrug，followedbytheenhancementofitsbioavailabilityAtfirst，aseriesofPDLLAnanospheresarepreparedbyadoubleemulsion—solventdiffusion

7、／evaporationmethodinthepurposeofdiscussingtheinfluenceofpreparingitemssuchasthePDLLAconcentrationthetypeofemulsifierandemulsionmethodonthecharacteristicsofnanospheresSEMandLaserparticlesizeanalysesareinvestigatedtocharac

8、terthemorphologyandsizedistributionofnanospheresThroughtheoptimizedconditionDNRcontainednanospheresarepreparedwithaaverageparticlesizeof540nln(ultrasound)and287nmfhomogenization)，andthedrugcontentsandloadingefficiencyare

9、14。34％，72。9％and184％，875％respectively，Inaddition，theDNR—loadednanospherescanreleasedrugcontinuallyintwoweekswhichshowsaprobableusingprospectThecurcuminloadedPDLLAnanoparticlesarepreparedthroughspontaneouselusionbinarysolv

10、entdiffusionmethodNanosphereswithanaveragediameterin300rimanddugcontentsin315％andloadingefficiencyin189％areobtained，TheDSCanalysisshowsthatcurcuminaredispersedorencapsulatedintothenanospheres，itcanconducetotheimprovement