CK7、CK20、villin等抗體聯(lián)合應(yīng)用對(duì)尋找來(lái)源不明轉(zhuǎn)移癌的實(shí)驗(yàn)研究意義.pdf

1、陜西中醫(yī)學(xué)院碩士學(xué)位論文CK7、CK20、villin等抗體聯(lián)合應(yīng)用對(duì)尋找來(lái)源不明轉(zhuǎn)移癌的實(shí)驗(yàn)研究意義姓名：王軍申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：中西醫(yī)結(jié)合基礎(chǔ)指導(dǎo)教師：王小平20100401StudyonsearchingtheiginofunknownmetastaticcarcinomasbyapplicationofcombinedCK7CK20villinantibodiesAbstractObjectiveTostudytheexpr

2、essionofCK7CK20villininmetastaticcarcinomaoflymphnodetoexplethevalueofthepanelofCK7CK20villinftheassignmentofalikelyprimarysiteofigininthemetastaticcarcinomaofthelymphnode.MethodsByimmunohistochemicalMaxvisionmethodexpre

3、ssionsofCK7CK20villinweredetectedin154casesofmetastaticcarcinomawithknownprimarieswhichincluding52casesofbreastcancer12casesofesophagealcancer28casesofgastriccancer12casesofcoloncancer16casesofrectalcancer9casesofgallbla

4、ddercarcinoma3casesoflaryngealcancer12casesoflungcancer6casesofprostatecancer.ResultsSevendifferentexpressionpatternsofCK7CK20villinwerefoundintheselymphnodemetastaticcarcinomawithknownprimaries:①CK7CK20villin:breastinva

5、sivelobularcarcinoma(100%)breastinfiltratingductalcarcinoma(100%)esophagealsquamouscellcarcinoma(100%)lungsquamouscellcarcinoma(33.3%)lungadenocarcinoma(83.3%)esophagealmucinousadenocarcinoma(100%)gastricadenocarcinoma(2

6、8.5%)colonadenocarcinoma(12.5%)laryngealsquamouscellcarcinoma(100%)②CK7CK20villin:gallbladderadenocarcinoma(66.7%)gastricadenocarcinoma(42.8%)prostatecancer(33.3%)③CK7CK20villin:lungsquamouscellcarcinoma(100%)lungadenoca

7、rcinoma(16.7%)prostatecancer(66.7%)rectalmucinousadenocarcinoma(50%)④CK7CK20villin:gastricadenocarcinoma(28.5%)⑤CK7CK20villin:colonadenocarcinoma(87.5%)colonmucinousadenocarcinoma(100%)⑥CK7CK20villin:rectaladenocarcinoma

8、(100%)rectalmucinousadenocarcinoma(50%)⑦CK7CK20villin:gallbladderadenocarcinoma(33.3%).ConclusionsCombineddetectionofCK7CK20villinmayhelptodeterminetheiginofmetastaticcarcinomaoflymphnodetodecreasethescopeofthemetastatic