自體外周血造血干細(xì)胞移植治療18例實(shí)體瘤的初步報(bào)告.pdf

1、青島大學(xué)碩士學(xué)位論文自體外周血造血干細(xì)胞移植治療18例實(shí)體瘤的初步報(bào)告姓名：魏紅梅申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：腫瘤學(xué)指導(dǎo)教師：陳維剛2002.4.1英文摘要THEPRELIMINARYREPROTOFAUTOLO—GoUSPERIPHERALBLOODSTEMCELLTRANSPLANTATION(APBSCT)FOR18PA—TIENTSWITHSOLIDTUMORSABSTRACTObjectiveTostudythefeasibili

2、tyandefficacyofhighdosechemotherapywiththesupportofautologousperipheralbloodstemcell(APBSC)forpatientsMethodsAtotalof18patientzwithsolidtumorsunderwentAPBSCTfromFehruary，1999Medianagewas40(12—76)18patientswerepathologica

3、llyconfirmed；Multiplemyeloma，lcase；Non—hodgkin’slymphoma，7cases；Smallcelllungcancer，1case；0varycancer，2cases；Breastcancer，4cases；andSofttissuesarcoma，3cases18patientsobtainedshrinkorremoraloflesionafterconventionaIchemot

4、herapy(CT)orsurgicaloperationTheperipheralbloodstemcell(PBSC)wasmobilizedbycombina—tionofchemotherapyandrecombinanthumangranulocytecolonystimulatingfactors(rhGCSF)APBSCwasharvestedbyCS3000PlusBloodCellSeparatoraftermobil

5、iza—tionTheenoughnumberofmononueleareell(MNC)andCD34cellwasobtainedbyPBSChavestingin1or2timesforeachpatientsThePBSCsof14patientswerestoredat4℃thentheconditioningregimenwasgivenandAPBSCswerereinfusedafter48hoursofCT，ThePB

6、SCsof4patientswerefrozenat一196℃Thepatients1ivedinahighlyefficientparticipateairfilteredroomuntilthereeonstitutionofthehematopoieticfunctionThepatientsleftthelaminarflowroomwhentheleucocytescountascendedmorethan1510。／LThe

7、patientswerereexaminedafter3weeks。thosewithresidualdiseasereceivedradiotherapyResultsTheoverallresponeratewas100％(CR67％，PR33％)Hematologicre—coverywasrapidWBCcountascendedbeyond10109／LOn10—12thdaytheplate—letcountwasbeyon

8、d5010。／Lon12—24thdayThemajortoxicitiesweremyelosup—pressionofIVgrade，gastroentericsidereaetion，mueusitisoforal—cavityandinfectionofrespiratorysystemNoneofthepatientswascomplicatedwithsevereothercomplica—tion，andtherewasn

9、otransplantation—relateddeathMedianfollowuptimewas6month(from3monthtol0month)10caseswerestillindiseasefreesurvival(DFS)。5caseswerediedofrecurrenceormatastasis，and3caseswereindiseasecompaningsurvival(DCS)ConclusionHighdos

10、echemotherapywithAPBSCsupportforsolidtumorwasef—fective，secure，feasibleThespeedofhematologicrecoveryisrelatedtothenumberofMNcFurtherstudiesonthechemorefactoryrecurrentpatientsareneededinthefu—tureKEYWORDS：solidtumor；APBS