胃腸道癌術后患者外周血淋巴細胞P16、cyclinD1異常表達的臨床意義.pdf

1、山西醫(yī)科大學碩士學位論文胃腸道癌術后患者外周血淋巴細胞P16、cyclinD1異常表達的臨床意義姓名：任曉輝申請學位級別：碩士專業(yè)：腫瘤學指導教師：裴毅20090423山西醫(yī)科人學碩Ij學位論文AbstractObiective：ToanalogytheclinicalsignificanceontheexpressionofP16andcyclinD1inbloodlymphocyteinpostoperativepatientwit

2、hgastrointestinalcancerMethods：FlowcytometrywasusedtodetecttheexpressionoftheP16andcyclinD1inbloodlymphocyteinthreegroups：43healthypeoplesforcontrolgroup，52patientswhowereoperatedasgastrointestinalcanceroneyearago，weredi

3、videdintostablegroupandadvancedgroupaccordingtotheclinicaloutcomeTheexpressioninthethreegroupswasanalogybyKruskal—WallisHtestandmannwhimeyUtest；DarwtheRoccurvetodefinitethecuritalvalue，andcalculatethesensitivityandspecif

4、icityoftheP16andcyclinDlResults：TheexpressionoftheP16andcyclinDlinperipheralbloodlymphocyteweresignificantlydifferentinthethreegroups(尸005)butTheexpressionoftheP16instablegroupwashigherthanthatincontrolgroup(尸O001)Drawth

5、eRoccurvetodefinitethecriticalvalueofrecidivision：P16was671，cyclinD1was622；Thesensitivityandspecificity；P16was824％、80O％，respectivelycyclinDlwas765％、857％，respectivelyFurthermore，thesensitivityandspecificityofthecombinativ

6、edetectionofthetwoindexwas824％、943％respectivelyConclusion：ItisimportantthatThehighexpressionoftheP16andcyclinD1inbloodlymphocytetojudgeoftherecidivationandprognosisofgastrointestinalcancerKeywords：gastrointestinalcancer；